Leishmaniasis affects 12 million people worldwide, with an estimated 2 million new infection occurring annually. All four main forms of disease, visceral (VL), cutaneous (CL), disseminated (DL) and mucosal leishmaniasis (ML), are prevalent in our study areas in the Northeast of Brazil. The main objective of this program is to expand and translate the knowledge acquired in the host parasite relationship in leishmaniasis to improve diagnose, establish new forms of therapy and to control leishmaniasis. The Federal University of Bahia (UFBA) Tropical Medicine Research Center was established in 1991. The Federal University of Rio Grande do Norte joined the TMRC in 1996 to share their expertise in VL. Strong collaborative programs have been established between Brazilian and US universities in Tropical diseases. This proposal entitled """"""""Host and Parasite Determinants in Human Leishmaniasis"""""""" has 4 cores (administrative, data management, epidemiology and transcriptomics) and 3 scientific projects. Project I """"""""Polymorphic features of Leishmania braziliensis: disease manifestations, geographic distribution, and genomes"""""""" will be use molecular and epidemiological tools to improve diagnosis associating genotype of parasite with clinical forms of leishmaniasis, as well as to identify isolates resistant to antimony therapy. Project II """"""""Protective and pathological immune response In L. braziliensis infection"""""""" will address the role of innate Immunity in control L. braziliensis infection in individuals with subclinical L. braziliensis infection as well as the role of CD8+T cells and macrophages in the pathology of American Tegumentary Leishmaniasis. Project III """"""""Genetic and Environmental Determinants of Symptomatic and Asymptomatic Leishmaniasis"""""""" will determine host genetic determinants affecting the outcome of visceral and tegumentary leishmaniasis, will perform transcriptome profiling of blood of VL patients in order to identify potential markers of progression or control f leishmania infection.
Leishmaniasis are in expansion and better diagnosis techniques and new forms of therapy are needed. Studies performed in this project will identify relevant aspects related to transmission of the disease, improve diagnosis and identify new forms of therapy.
|ConceiÃ§Ã£o, Jacilara; Davis, Richard; Carneiro, Pedro Paulo et al. (2016) Characterization of Neutrophil Function in Human Cutaneous Leishmaniasis Caused by Leishmania braziliensis. PLoS Negl Trop Dis 10:e0004715|
|de Oliveira Mendes-Aguiar, C; Vieira-GonÃ§alves, R; GuimarÃ£es, L H et al. (2016) Effector memory CD4(+) T cells differentially express activation associated molecules depending on the duration of American cutaneous leishmaniasis lesions. Clin Exp Immunol 185:202-9|
|Carneiro, Pedro Paulo; ConceiÃ§Ã£o, Jacilara; Macedo, Michael et al. (2016) The Role of Nitric Oxide and Reactive Oxygen Species in the Killing of Leishmania braziliensis by Monocytes from Patients with Cutaneous Leishmaniasis. PLoS One 11:e0148084|
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|Oliveira, Joyce Moura; RÃªgo, Jamile LeÃ£o; de Lima Santana, Nadja et al. (2016) The -308 bp TNF gene polymorphism influences tumor necrosis factor expression in leprosy patients in Bahia State, Brazil. Infect Genet Evol 39:147-54|
|Muniz, Aline C; Bacellar, OlÃvia; Lago, Ednaldo Lima et al. (2016) Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study. J Infect Dis 214:570-6|
|Schaut, Robert G; Lamb, Ian M; Toepp, Angela J et al. (2016) Regulatory IgDhi B Cells Suppress T Cell Function via IL-10 and PD-L1 during Progressive Visceral Leishmaniasis. J Immunol 196:4100-9|
|Carvalho, Augusto M; Amorim, Camila F; Barbosa, Juliana L S et al. (2015) Age modifies the immunologic response and clinical presentation of American tegumentary leishmaniasis. Am J Trop Med Hyg 92:1173-7|
|Esch, Kevin J; Schaut, Robert G; Lamb, Ian M et al. (2015) Activation of autophagy and nucleotide-binding domain leucine-rich repeat-containing-like receptor family, pyrin domain-containing 3 inflammasome during Leishmania infantum-associated glomerulonephritis. Am J Pathol 185:2105-17|
|Gimblet, Ciara; Loesche, Michael A; Carvalho, Lucas et al. (2015) IL-22 Protects against Tissue Damage during Cutaneous Leishmaniasis. PLoS One 10:e0134698|
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