instructions): Demographic Surveillance Systems (DSS) around the world have been a crucial tool to evaluate public health intervenfions and conduct relevant epidemiological studies in areas where basic demographic, social and health data are not available. DSS field sites confinuously collect data on births, deaths (including causes) and migration which provide an important resource for evaluating the impact of health care interventions. They also offer an interesting starting point for new studies. The goal of Scientific Core C is to establish a Demographic Surveillance System covering over 125,000 people in Muzaffarpur, one of the Visceral Leishmaniasis (VL) endemic districts in Bihar (India) in two phases. During phase-1, the DSS will be developed in the area where the ongoing TMRC project is implemented (85,000 people). In phase-2, DSS will be extended to the adjacent areas ofthe current TMRC area covering another 40,000 people where the VL prevalence is expected to be high as the coverage by the elimination program is low. The TMRC-lndia DSS will be the first demographic platform in a VL endemic area and it will be pioneering on VL research. The TMRC-lndia DSS will be: 1. A training platform for local staff and researchers in epidemiology, demography, entomology, DSS management and other disciplines related to intervenfion studies. 2. A research platform to conduct field studies for projects 1 and 2 in the current proposal as well as future epidemiological and intervenfion studies on VL (i.e. vaccine trial) and other disease or social issues relevant in rural Bihar. The Scientific Core C is designed to ensure that the TMRC-lndia DSS becomes a stable and solid research and training platform in India. This will promote the long-term collaboration between the different participants in this proposal and will attract new institutions and researchers.

Public Health Relevance

The TMRC-lndia DSS will provide an excellent platform to conduct epidemiological studies and evaluate public health interventions on Visceral Leishmaniasis and other health issues affecting the poor rural communities in Bihar. The DSS will be used to conduct the fieldwork for projects 1 and 2 of this renewal application as well as a platform to train researchers and conduct intervention studies (e.g. vaccine trials) in the near future

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Specialized Center (P50)
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Special Emphasis Panel (ZAI1-AWA-M (J1))
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Banaras Hindu University
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Sundar, Shyam; Chakravarty, Jaya (2015) An update on pharmacotherapy for leishmaniasis. Expert Opin Pharmacother 16:237-52
Malaviya, Paritosh; Picado, Albert; Hasker, Epco et al. (2014) Health & Demographic Surveillance System profile: the Muzaffarpur-TMRC Health and Demographic Surveillance System. Int J Epidemiol 43:1450-7
Mudavath, Shyam Lal; Talat, Mahe; Rai, Madhukar et al. (2014) Characterization and evaluation of amine-modified graphene amphotericin B for the treatment of visceral leishmaniasis: in vivo and in vitro studies. Drug Des Devel Ther 8:1235-47
Hasker, Epco; Malaviya, Paritosh; Gidwani, Kamlesh et al. (2014) Strong association between serological status and probability of progression to clinical visceral leishmaniasis in prospective cohort studies in India and Nepal. PLoS Negl Trop Dis 8:e2657
Singh, Om Prakash; Hasker, Epco; Sacks, David et al. (2014) Asymptomatic Leishmania infection: a new challenge for Leishmania control. Clin Infect Dis 58:1424-9
Kumar, R; Singh, O P; Gautam, S et al. (2014) Enhanced expression of Toll-like receptors 2 and 4, but not 9, in spleen tissue from patients with visceral leishmaniasis. Parasite Immunol 36:721-5
Kumar, Dinesh; Tiwary, Puja; Chakravarty, Jaya et al. (2014) Association of interleukin-18 gene polymorphism with susceptibility to visceral leishmaniasis in endemic area of Bihar, an Indian population. ScientificWorldJournal 2014:852104
Singh, Om Prakash; Sundar, Shyam (2014) Whole blood assay and visceral leishmaniasis: Challenges and promises. Immunobiology 219:323-8
Sudarshan, Medhavi; Sundar, Shyam (2014) Parasite load estimation by qPCR differentiates between asymptomatic and symptomatic infection in Indian visceral leishmaniasis. Diagn Microbiol Infect Dis 80:40-2
Gautam, Shalini; Kumar, Rajiv; Singh, Neetu et al. (2014) CD8 T cell exhaustion in human visceral leishmaniasis. J Infect Dis 209:290-9

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