Core A: The program will be coordinated at Banaras Hindu University, through the efforts of the Administrative Core and the Data Management and Biostatistics Core.
Specific aims of the program are: 1. To provide administrative coordination of the two scientific cores, the four research projects and the Data Management &Biostatistics core ofthe TMRC program. This will include communication with collaborating investigators at institutions within and outside of India, communication with NIH personnel, and assurance of compliance with NIH requirements. 2. To provide financial accounting and oversight of finances at BHU, KAMRC in Muzaffarpur, Institute of Tropical Medicine in Belgium, the University of Western Australia and the University of lowa. This will include distribution of funds, payment of salaries and overall accounting of expenses. 3. To perform the day to day management of the projects. This will involve purchase and distribution of equipment and research supplies, management of personnel, coordination of publications, and arranging communication between investigators on specific projects. 4. To coordinate meetings and training activities. Key activities are (A) the annual TMRC meeting in Varanasi, India, which is attended by participating TMRC scientists and administrators from BHU and Muzaffarpur, and by collaborating investigators from other universities in India, the USA, Australia and Belgium;(B) travel and housing for Indian investigators to participate in scientific meetings, short courses, or short term training experiences in labs at collaborating universities.

Public Health Relevance

Administrative core will coordinate the hwo scientific cores, data management and Bio-statistics core and four research projects ofthe TMRC Program and plays a very important role for smooth running ofthe projects and cores and ensures compliance with the NIH policies and guidelines.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Specialized Center (P50)
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Special Emphasis Panel (ZAI1-AWA-M)
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Banaras Hindu University
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Singh, Neetu; Kumar, Rajiv; Engwerda, Christian et al. (2016) Tumor necrosis factor alpha neutralization has no direct effect on parasite burden, but causes impaired IFN-γ production by spleen cells from human visceral leishmaniasis patients. Cytokine 85:184-90
Sudarshan, Medhavi; Singh, Toolika; Singh, Bhawana et al. (2016) Suppression of host PTEN gene expression for Leishmania donovani survival in Indian visceral leishmaniasis. Microbes Infect 18:369-72
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Montes de Oca, Marcela; Kumar, Rajiv; de Labastida Rivera, Fabian et al. (2016) Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology. PLoS Pathog 12:e1005398
Singh, Om Prakash; Singh, Bhawana; Chakravarty, Jaya et al. (2016) Current challenges in treatment options for visceral leishmaniasis in India: a public health perspective. Infect Dis Poverty 5:19
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Sundar, Shyam; Singh, Anup (2016) Recent developments and future prospects in the treatment of visceral leishmaniasis. Ther Adv Infect Dis 3:98-109
Faleiro, Rebecca J; Kumar, Rajiv; Bunn, Patrick T et al. (2016) Combined Immune Therapy for the Treatment of Visceral Leishmaniasis. PLoS Negl Trop Dis 10:e0004415
Singh, Om Prakash; Sundar, Shyam (2015) Developments in Diagnosis of Visceral Leishmaniasis in the Elimination Era. J Parasitol Res 2015:239469
Ghosh, Prakash; Hasnain, Md Golam; Ghosh, Debashis et al. (2015) A comparative evaluation of the performance of commercially available rapid immunochromatographic tests for the diagnosis of visceral leishmaniasis in Bangladesh. Parasit Vectors 8:331

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