Core A: The program will be coordinated at Banaras Hindu University, through the efforts of the Administrative Core and the Data Management and Biostatistics Core.
Specific aims of the program are: 1. To provide administrative coordination of the two scientific cores, the four research projects and the Data Management &Biostatistics core ofthe TMRC program. This will include communication with collaborating investigators at institutions within and outside of India, communication with NIH personnel, and assurance of compliance with NIH requirements. 2. To provide financial accounting and oversight of finances at BHU, KAMRC in Muzaffarpur, Institute of Tropical Medicine in Belgium, the University of Western Australia and the University of lowa. This will include distribution of funds, payment of salaries and overall accounting of expenses. 3. To perform the day to day management of the projects. This will involve purchase and distribution of equipment and research supplies, management of personnel, coordination of publications, and arranging communication between investigators on specific projects. 4. To coordinate meetings and training activities. Key activities are (A) the annual TMRC meeting in Varanasi, India, which is attended by participating TMRC scientists and administrators from BHU and Muzaffarpur, and by collaborating investigators from other universities in India, the USA, Australia and Belgium;(B) travel and housing for Indian investigators to participate in scientific meetings, short courses, or short term training experiences in labs at collaborating universities.

Public Health Relevance

Administrative core will coordinate the hwo scientific cores, data management and Bio-statistics core and four research projects ofthe TMRC Program and plays a very important role for smooth running ofthe projects and cores and ensures compliance with the NIH policies and guidelines.

National Institute of Health (NIH)
Specialized Center (P50)
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Special Emphasis Panel (ZAI1)
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Banaras Hindu University
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Sundar, Shyam; Chakravarty, Jaya (2015) An update on pharmacotherapy for leishmaniasis. Expert Opin Pharmacother 16:237-52
Malaviya, Paritosh; Picado, Albert; Hasker, Epco et al. (2014) Health & Demographic Surveillance System profile: the Muzaffarpur-TMRC Health and Demographic Surveillance System. Int J Epidemiol 43:1450-7
Mudavath, Shyam Lal; Talat, Mahe; Rai, Madhukar et al. (2014) Characterization and evaluation of amine-modified graphene amphotericin B for the treatment of visceral leishmaniasis: in vivo and in vitro studies. Drug Des Devel Ther 8:1235-47
Hasker, Epco; Malaviya, Paritosh; Gidwani, Kamlesh et al. (2014) Strong association between serological status and probability of progression to clinical visceral leishmaniasis in prospective cohort studies in India and Nepal. PLoS Negl Trop Dis 8:e2657
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Singh, Om Prakash; Sundar, Shyam (2014) Whole blood assay and visceral leishmaniasis: Challenges and promises. Immunobiology 219:323-8
Sudarshan, Medhavi; Sundar, Shyam (2014) Parasite load estimation by qPCR differentiates between asymptomatic and symptomatic infection in Indian visceral leishmaniasis. Diagn Microbiol Infect Dis 80:40-2
Gautam, Shalini; Kumar, Rajiv; Singh, Neetu et al. (2014) CD8 T cell exhaustion in human visceral leishmaniasis. J Infect Dis 209:290-9

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