The overall aim of this Project 1 is to accelerate the development of recombinant paramyosin as a vaccine against schistosomiasisjaponica. Schistosomiasis, caused by three principle species of dioecious trematodes (flatworms), currently infects over 250 million individuals, results in 1.53 million DALYs lost per annum, and contributes to poor health and economic stagnation in endemic areas. Although schistosomiasis is effectively treated with Praziquantel (PZQ), rapid reinfection with rebound morbidity precludes effective control based on chemotherapy alone and justifies current efforts to develop vaccines for these parasites. We will evaluate the efficacy and safety of paramyosin (rSj97), the target of protective Th2 and IgE responses in our human studies, in vaccine trials in water buffalo- a major bovine reservoir of schistosomiasis. We will explore a range of vaccine adjuvants in field- based challenge experiments in water buffalos. We will conclude with a large scale, community based vaccine trial in buffalo designed to test the hypothesis that effective vaccination of water buffalo will reduce the transmission of schistosomiasis japonica to humans. The outcome of these studies will be an optimized, adjuvanted, paramyosin-based vaccine for bovine schistosomiasisjaponica with preclinical data on safety and efficacy in a large animal model.

Public Health Relevance

Vaccine development for schistosomiasis remains a promising avenue to better control this chronic and debilitating disease. This TMRC project will provide a strong basis to deploy a bovine vaccine and will support an FDA IND application for follow-on Phase l/ll clinical trials to develop a human vaccine that limits reinfection and consequent morbidity and mortality.

Agency
National Institute of Health (NIH)
Type
Specialized Center (P50)
Project #
5P50AI098481-03
Application #
8716653
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Research Institute for Tropical Medicine
Department
Type
DUNS #
City
Muntinlupa City
State
Country
Philippines
Zip Code
1781
Olveda, David U; Olveda, Remigio M; Lam, Alfred K et al. (2014) Utility of Diagnostic Imaging in the Diagnosis and Management of Schistosomiasis. Clin Microbiol 3:
Inobaya, Marianette T; Olveda, Remigio M; Chau, Thao Np et al. (2014) Prevention and control of schistosomiasis: a current perspective. Res Rep Trop Med 2014:65-75