There is limited knowledge of leishmaniasis in West Africa including the environmental factors affecting this disease, the role of vector saliva in leishmaniasis and the role of other pathogens in the development of this neglected disease. Recent studies in Mali and Ghana enabled us to formulate more comprehensive questions and propose new hypothesis to increase our understanding of the transmission and development of cutaneous leishmaniasis in the field with the objective to identify novel ways to prevent and treat this neglected disease. The major specific aim of this proposal is to: understand the association of immune responses of individuals living in endemic areas to vector salivary proteins in the development of leishmaniasis and importantly, how these immune responses may be modulated by co-infections with filarial worms. Findings of these study will contribute to guide vaccine development based on salivary gland proteins. The long-term objectives of the Administrative Core are to: 1] develop expertise in research administration for each institution involved, 2] provide leadership on administrative issues related to health research, and 3] to contribute in the training of individuals (capacity building) to ensure self-sustaining research and networks on neglected tropical diseases with other Tropical Medicine Research Center. More specifically, the administrative core will 1] Track scientific progress and accomplishments for each of the individual projects and cores;2] Identify and ensure the coordination of related studies at different field sites and laboratories;3] Ensure compliance with IRBs and other regulatory authorities for studies of human subjects;4] Develop administrative guidelines to define the responsibilities of investigators, and to ensure the responsible management of funds provided for these studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
4P50AI098505-02
Application #
8515890
Study Section
Special Emphasis Panel (ZAI1-AWA-M)
Project Start
2013-08-01
Project End
2017-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
2
Fiscal Year
2013
Total Cost
$54,761
Indirect Cost
$2,746
Name
University of Bamako
Department
Type
DUNS #
565539819
City
Bamako
State
Country
Mali
Zip Code
BP E2-528