There is limited knowledge of leishmaniasis in West Africa including the environmental factors affecting this disease, the role of vector saliva in leishmaniasis and the role of other pathogens in the development of this neglected disease. Recent studies in Mali and Ghana enabled us to formulate more comprehensive questions and propose new hypothesis to increase our understanding of the transmission and development of cutaneous leishmaniasis in the field with the objective to identify novel ways to prevent and treat this neglected disease. The major specific aim of this proposal is to: understand the association of immune responses of individuals living in endemic areas to vector salivary proteins in the development of leishmaniasis and importantly, how these immune responses may be modulated by co-infections with filarial worms. Findings of these study will contribute to guide vaccine development based on salivary gland proteins. The long-term objectives of the Administrative Core are to: 1] develop expertise in research administration for each institution involved, 2] provide leadership on administrative issues related to health research, and 3] to contribute in the training of individuals (capacity building) to ensure self-sustaining research and networks on neglected tropical diseases with other Tropical Medicine Research Center. More specifically, the administrative core will 1] Track scientific progress and accomplishments for each of the individual projects and cores;2] Identify and ensure the coordination of related studies at different field sites and laboratories;3] Ensure compliance with IRBs and other regulatory authorities for studies of human subjects;4] Develop administrative guidelines to define the responsibilities of investigators, and to ensure the responsible management of funds provided for these studies.
|Sangare, Moussa Brema; Coulibaly, Yaya Ibrahim; Coulibaly, Siaka Yamoussa et al. (2018) A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali. Parasit Vectors 11:18|
|Coulibaly, Cheick Amadou; Traore, Bourama; Dicko, Adama et al. (2018) Impact of insecticide-treated bednets and indoor residual spraying in controlling populations of Phlebotomus duboscqi, the vector of Leishmania major in Central Mali. Parasit Vectors 11:345|
|Touré, Mahamoudou; Petersen, Pelle T; Bathily, Sidy N'd et al. (2017) Molecular Evidence of Malaria and Zoonotic Diseases Among Rapid Diagnostic Test-Negative Febrile Patients in Low-Transmission Season, Mali. Am J Trop Med Hyg 96:335-337|
|Traoré, Bourama; Oliveira, Fabiano; Faye, Ousmane et al. (2017) Correction: Prevalence of Cutaneous Leishmaniasis in Districts of High and Low Endemicity in Mali. PLoS Negl Trop Dis 11:e0005379|
|Traoré, Bourama; Oliveira, Fabiano; Faye, Ousmane et al. (2016) Prevalence of Cutaneous Leishmaniasis in Districts of High and Low Endemicity in Mali. PLoS Negl Trop Dis 10:e0005141|
|Coulibaly, C A; Sissoko, I; Traore, B et al. (2016) Diversity of Sand Flies (Diptera: Psychodidae: Phlebotominae) in Two Different Eco-Climatic and Endemic Zones of Cutaneous Leishmaniasis in Mali, West Africa. J Med Entomol 53:923-927|
|Wei, Stanley C; Vanden Eng, Jodi L; Patterson, Amy E et al. (2012) Validity of Expanded Program on Immunization Contact Method health behavior estimates in Mali. J Infect Dis 205 Suppl 1:S112-9|