This TMRC application deals with the neglected tropical disease, opisthorchiasis, caused by infection with the fish-borne trematode parasite, Opisthorchis viverrini. Chronic opisthorchiasis often culminates cholangiocarcinoma, cancer of the bile ducts. This TMRC application takes place in Khon Kaen Province, on the Khorat Plateau in northeastern Thailand. The research draws together a diverse team of researchers with expertise in carcinogenesis, molecular and immuno-parasitology, pathogenesis, biostatistics, epidemiology and transmission modeling. The proposed research, which includes three scientific projects and two cores, addresses major gaps in our current understanding of carcinogenesis, host-susceptibility and the ecology of O. viverrini transmission. While our research focuses specifically on O. viverrini, the research has implications for the control of other carcinogenic liver flukes, particularly, Clonorchis sinensis. Together, these parasites infec an estimated 45 million people in Southeast Asia, China and the Koreas, with infections and associated malignancies concentrated in the rural poor. The proposal includes three scientific projects and two cores. The scientific goals of this TMRC involve characterizing human phenotypic markers displayed by infected humans who are at risk of cholangiocarcinoma caused by O. viverrini. In particular, we will compare and contrast immunological and inflammatory profiles of individuals whose liver (periportal) fibrosis do or does not resolve after medication with praziquantel to remove the parasite infection. These comparisons can be predicted to deliver markers that predict progression to advanced liver fibrosis and indeed cholangiocarcinoma from among the millions of persons infected with O. viverrini, and perhaps also from the many millions more infected with related liver flukes, including Clonorchis sinensis in Vietnam, China and the Koreas.

Public Health Relevance

This project offers to shed light on the cause and mechanism of pathogenesis and carcinogenesis caused by infection with the liver fluke (Opisthorchis viverrini) and also providing means to sustainably reduce O. viverrini infection prevalence and associated morbidity in endemic countries in Southeast Asia as well as China and Korea where the other liver fluke (Clonorchis sinensis) is also a public health problem

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
1P50AI098639-01
Application #
8264817
Study Section
Special Emphasis Panel (ZAI1-AWA-M (J1))
Program Officer
Rao, Malla R
Project Start
2012-08-01
Project End
2013-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
1
Fiscal Year
2012
Total Cost
$312,883
Indirect Cost
$22,769
Name
Khon Kaen University
Department
Type
DUNS #
659454446
City
Khon Kaen
State
Country
Thailand
Zip Code
40002
Sripa, Banchob; Tangkawattana, Sirikachorn; Sangnikul, Thinnakorn (2016) The Lawa model: A sustainable, integrated opisthorchiasis control program using the EcoHealth approach in the Lawa Lake region of Thailand. Parasitol Int :
Teimoori, Salma; Arimatsu, Yuji; Laha, Thewarach et al. (2016) Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis. Parasitol Int :
Sereerak, Piya; Upontain, Songkaid; Tangkawattana, Prasarn et al. (2016) Efficacious and safe dose of praziquantel for the successful treatment of feline reservoir hosts with opisthorchiasis. Parasitol Int :
Sripa, Banchob; Deenonpoe, Raksawan; Brindley, Paul J (2016) Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma? Parasitol Int :
Van, Chinh Dang; Doungchawee, Galayanee; Suttiprapa, Sutas et al. (2016) Association between Opisthorchis viverrini and Leptospira spp. infection in endemic Northeast Thailand. Parasitol Int :
Echaubard, Pierre; Sripa, Banchob; Mallory, Frank F et al. (2016) The role of evolutionary biology in research and control of liver flukes in Southeast Asia. Infect Genet Evol 43:381-97
Saltykova, Irina V; Ogorodova, Ludmilla M; Ivanov, Vladimir V et al. (2016) Carbonyl stress phenomena during chronic infection with Opisthorchis felineus. Parasitol Int :
Chaiyadet, Sujittra; Smout, Michael; Laha, Thewarach et al. (2016) Proteomic characterization of the internalization of Opisthorchis viverrini excretory/secretory products in human cells. Parasitol Int :
Vinh, Hoang Quang; Phimpraphai, Waraphon; Tangkawattana, Sirikachorn et al. (2016) Risk factors for Clonorchis sinensis infection transmission in humans in northern Vietnam: A descriptive and social network analysis study. Parasitol Int 66:74-82
Laohaviroj, Marut; Chamgramol, Yaovalux; Pairojkul, Chawalit et al. (2016) Clinicopathological Significance of Osteopontin in Cholangiocarcinoma Cases. Asian Pac J Cancer Prev 17:201-5

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