instnjctions): During chronic opisthorchiasis, pathogenesis is manifested in a series of well-defined stages as the normal tissue architecture of the biliary epithelium is progressively remodeled by the chronic inflammatory response from repeated injury sustained by the biliary epithelium from a combinafion ofthe mechanical, toxic, and immune mechanisms of the fluke in the bile duct. As individuals are infected with O. viverrini for many years (often a lifetime), a persistent cycle of fissue damage and repair takes place in the intrahepafic biliary ducts, creafing a chronic inflammatory milieu that stimulates periductal fibrogenesis and provides the

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
1P50AI098639-01
Application #
8304519
Study Section
Special Emphasis Panel (ZAI1-AWA-M (J1))
Project Start
Project End
2013-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
1
Fiscal Year
2012
Total Cost
$156,381
Indirect Cost
$11,381
Name
Khon Kaen University
Department
Type
DUNS #
659454446
City
Khon Kaen
State
Country
Thailand
Zip Code
40002
Sripa, Banchob; Tangkawattana, Sirikachorn; Sangnikul, Thinnakorn (2016) The Lawa model: A sustainable, integrated opisthorchiasis control program using the EcoHealth approach in the Lawa Lake region of Thailand. Parasitol Int :
Teimoori, Salma; Arimatsu, Yuji; Laha, Thewarach et al. (2016) Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis. Parasitol Int :
Sereerak, Piya; Upontain, Songkaid; Tangkawattana, Prasarn et al. (2016) Efficacious and safe dose of praziquantel for the successful treatment of feline reservoir hosts with opisthorchiasis. Parasitol Int :
Sripa, Banchob; Deenonpoe, Raksawan; Brindley, Paul J (2016) Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma? Parasitol Int :
Van, Chinh Dang; Doungchawee, Galayanee; Suttiprapa, Sutas et al. (2016) Association between Opisthorchis viverrini and Leptospira spp. infection in endemic Northeast Thailand. Parasitol Int :
Echaubard, Pierre; Sripa, Banchob; Mallory, Frank F et al. (2016) The role of evolutionary biology in research and control of liver flukes in Southeast Asia. Infect Genet Evol 43:381-97
Saltykova, Irina V; Ogorodova, Ludmilla M; Ivanov, Vladimir V et al. (2016) Carbonyl stress phenomena during chronic infection with Opisthorchis felineus. Parasitol Int :
Chaiyadet, Sujittra; Smout, Michael; Laha, Thewarach et al. (2016) Proteomic characterization of the internalization of Opisthorchis viverrini excretory/secretory products in human cells. Parasitol Int :
Vinh, Hoang Quang; Phimpraphai, Waraphon; Tangkawattana, Sirikachorn et al. (2016) Risk factors for Clonorchis sinensis infection transmission in humans in northern Vietnam: A descriptive and social network analysis study. Parasitol Int 66:74-82
Laohaviroj, Marut; Chamgramol, Yaovalux; Pairojkul, Chawalit et al. (2016) Clinicopathological Significance of Osteopontin in Cholangiocarcinoma Cases. Asian Pac J Cancer Prev 17:201-5

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