Abstract

instnjctions): During chronic opisthorchiasis, pathogenesis is manifested in a series of well-defined stages as the normal tissue architecture of the biliary epithelium is progressively remodeled by the chronic inflammatory response from repeated injury sustained by the biliary epithelium from a combinafion ofthe mechanical, toxic, and immune mechanisms of the fluke in the bile duct. As individuals are infected with O. viverrini for many years (often a lifetime), a persistent cycle of fissue damage and repair takes place in the intrahepafic biliary ducts, creafing a chronic inflammatory milieu that stimulates periductal fibrogenesis and provides the

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
1P50AI098639-01
Application #
8304519
Study Section
Special Emphasis Panel (ZAI1-AWA-M (J1))
Project Start
Project End
2013-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
1
Fiscal Year
2012
Total Cost
$156,381
Indirect Cost
$11,381

  Institution

Name
Khon Kaen University
Department
Type
DUNS #
659454446
City
Khon Kaen
State
Country
Thailand
Zip Code
40002

  Publications

Chaiyadet, Sujittra; Smout, Michael; Laha, Thewarach et al. (2017) Proteomic characterization of the internalization of Opisthorchis viverrini excretory/secretory products in human cells. Parasitol Int 66:494-502
Deenonpoe, Raksawan; Mairiang, Eimorn; Mairiang, Pisaln et al. (2017) Elevated prevalence of Helicobacter species and virulence factors in opisthorchiasis and associated hepatobiliary disease. Sci Rep 7:42744
van Tong, Hoang; Brindley, Paul J; Meyer, Christian G et al. (2017) Parasite Infection, Carcinogenesis and Human Malignancy. EBioMedicine 15:12-23
Sripa, Banchob; Deenonpoe, Raksawan; Brindley, Paul J (2017) Co-infections with liver fluke and Helicobacter species: A paradigm change in pathogenesis of opisthorchiasis and cholangiocarcinoma? Parasitol Int 66:383-389
Kim, Christina Sunyoung; Smith, John F; Suwannatrai, Apiporn et al. (2017) Role of socio-cultural and economic factors in cyprinid fish distribution networks and consumption in Lawa Lake region, Northeast Thailand: Novel perspectives on Opisthorchis viverrini transmission dynamics. Acta Trop 170:85-94
Echaubard, Pierre; León, Tomas; Suwanatrai, Kulwadee et al. (2017) Experimental and modelling investigations of Opisthorchis viverrini miracidia transmission over time and across temperatures: implications for control. Int J Parasitol 47:257-270
Vinh, Hoang Quang; Phimpraphai, Waraphon; Tangkawattana, Sirikachorn et al. (2017) Risk factors for Clonorchis sinensis infection transmission in humans in northern Vietnam: A descriptive and social network analysis study. Parasitol Int 66:74-82
Van, Chinh Dang; Doungchawee, Galayanee; Suttiprapa, Sutas et al. (2017) Association between Opisthorchis viverrini and Leptospira spp. infection in endemic Northeast Thailand. Parasitol Int 66:503-509
Hanpanich, Petcharakorn; Laha, Thewarach; Sripa, Banchob et al. (2017) Decreased risk of cholangiocarcinogenesis following repeated cycles of Opisthorchis viverrini infection-praziquantel treatment: Magnetic Resonance Imaging (MRI) and histopathological study in a hamster model. Parasitol Int 66:464-470
Maksimova, Galina A; Pakharukova, Maria Y; Kashina, Elena V et al. (2017) Effect of Opisthorchis felineus infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian hamsters. Parasitol Int 66:458-463

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