instnjctions): During chronic opisthorchiasis, pathogenesis is manifested in a series of well-defined stages as the normal tissue architecture of the biliary epithelium is progressively remodeled by the chronic inflammatory response from repeated injury sustained by the biliary epithelium from a combinafion ofthe mechanical, toxic, and immune mechanisms of the fluke in the bile duct. As individuals are infected with O. viverrini for many years (often a lifetime), a persistent cycle of fissue damage and repair takes place in the intrahepafic biliary ducts, creafing a chronic inflammatory milieu that stimulates periductal fibrogenesis and provides the

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center (P50)
Project #
1P50AI098639-01
Application #
8304519
Study Section
Special Emphasis Panel (ZAI1-AWA-M (J1))
Project Start
Project End
2013-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
1
Fiscal Year
2012
Total Cost
$156,381
Indirect Cost
$11,381
Name
Khon Kaen University
Department
Type
DUNS #
659454446
City
Khon Kaen
State
Country
Thailand
Zip Code
40002
Thanasuwan, Sirikanda; Piratae, Supawadee; Brindley, Paul J et al. (2014) Suppression of aquaporin, a mediator of water channel control in the carcinogenic liver fluke, Opisthorchis viverrini. Parasit Vectors 7:224
Thi Phung, Luyen; Loukas, Alex; Brindley, Paul J et al. (2014) Retrotransposon OV-RTE-1 from the carcinogenic liver fluke Opisthorchis viverrini: potential target for DNA-based diagnosis. Infect Genet Evol 21:443-51
Plieskatt, Jordan L; Rinaldi, Gabriel; Feng, Yanjun et al. (2014) Distinct miRNA signatures associate with subtypes of cholangiocarcinoma from infection with the tumourigenic liver fluke Opisthorchis viverrini. J Hepatol 61:850-8
Plieskatt, Jordan L; Deenonpoe, Raksawan; Mulvenna, Jason P et al. (2013) Infection with the carcinogenic liver fluke Opisthorchis viverrini modifies intestinal and biliary microbiome. FASEB J 27:4572-84
Saichua, Prasert; Sithithaworn, Paiboon; Jariwala, Amar R et al. (2013) Microproteinuria during Opisthorchis viverrini infection: a biomarker for advanced renal and hepatobiliary pathologies from chronic opisthorchiasis. PLoS Negl Trop Dis 7:e2228