The major goal of the Psoriasis CORT at Case is to integrate basic, clinical and translational resources inorder to promote the progress and quality of research in psoriasis. In order to accomplish this, the CORT willadd two cores to the array of fully functional existing cores within the Skin Diseases Research Center. TheBiostatistics Core will provide appropriate methodological support for skin-related research through arecognized and accessible central unit. By integrating three complementary functions -service, researchand education - the efficiency and quality of research endeavors of CORT investigators will be boosted. Theservices covered will range from the assistance in planning and analysis of protocols and writing ofmanuscripts, to the provision of computational resources. Also, a wide range of specialized analyses will beprovided, including study design, survival, longitudinal, multivariate, diagnostic testing, statistical imageanalysis, meta-analysis, and consultation on microarray data. The latter will constitute the bridge betweenthe operations of the Biostatistics and the Systems Biology Cores, extensively used by the four projects ofthe CORT. Finally, an education mission focused on principles of experimental and clinical research designwill allow investigators to conceptualize their studies in a more efficient way.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Case Western Reserve University
United States
Zip Code
Soler, David C; Ohtola, Jennifer; Sugiyama, Hideaki et al. (2016) Activated T cells exhibit increased uptake of silicon phthalocyanine Pc 4 and increased susceptibility to Pc 4-photodynamic therapy-mediated cell death. Photochem Photobiol Sci 15:822-31
Santilli, S; Kast, D R; Grozdev, I et al. (2016) Visualization of atherosclerosis as detected by coronary artery calcium and carotid intima-media thickness reveals significant atherosclerosis in a cross-sectional study of psoriasis patients in a tertiary care center. J Transl Med 14:217
Wang, Yunmei; Golden, Jackelyn B; Fritz, Yi et al. (2016) Interleukin 6 regulates psoriasiform inflammation-associated thrombosis. JCI Insight 1:e89384
Hawkes, Jason E; Gudjonsson, Johann E; Ward, Nicole L (2016) The Snowballing Literature on Imiquimod-Induced Skin Inflammation in Mice: A Critical Appraisal. J Invest Dermatol :
Ward, Nicole L; Bhagathavula, Narasimharao; Johnston, Andrew et al. (2015) Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture. J Invest Dermatol 135:910-3
Lundberg, Kathleen C; Fritz, Yi; Johnston, Andrew et al. (2015) Proteomics of skin proteins in psoriasis: from discovery and verification in a mouse model to confirmation in humans. Mol Cell Proteomics 14:109-19
Mirmirani, P; Consolo, M; Oyetakin-White, P et al. (2015) Similar response patterns to topical minoxidil foam 5% in frontal and vertex scalp of men with androgenetic alopecia: a microarray analysis. Br J Dermatol 172:1555-61
Soler, D C; Bai, X; Ortega, L et al. (2015) The key role of aquaporin 3 and aquaporin 10 in the pathogenesis of pompholyx. Med Hypotheses 84:498-503
Golden, Jackelyn B; Groft, Sarah G; Squeri, Michael V et al. (2015) Chronic Psoriatic Skin Inflammation Leads to Increased Monocyte Adhesion and Aggregation. J Immunol 195:2006-18
Foster, Alexander M; Baliwag, Jaymie; Chen, Cynthia S et al. (2014) IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin. J Immunol 192:6053-61

Showing the most recent 10 out of 37 publications