Abstract

We propose a Joint Trauma Biomarker Core to oversee all molecular biomarker studies proposed in CORT projects. The Core will provide crucial technical support in the form of validated assays for the OARSI-recommended biomarkers proposed in Projects 2 and 3. In addition, the Core will establish and maintain a comprehensive repository of synovial fluids and sera from animals and patients. This repository will be accessed for advanced biomarker studies predicated on new findings emerging from CORT research. Finally, the Core will foster the development of novel mathematical models of joint injuries for testing functional relationships between biomarkers and joint degeneration. Thus, in addition to assay services the Core will offer resources for testing new biomarker-related hypotheses that flow from CORT discoveries.

Public Health Relevance

Synovial fluid and serum biomarkers will be collected and studied in CORT projects to better understand their relationship to OA in various injury scenarios. The overall goal of the Joint Trauma Biomarker Core will be to realize the immense potential for biomarker discovery embodied in these large, fully documented sample collections. This will require close coordination among different labs and investigators, a need best filled by a centralized Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR055533-07
Application #
8539466
Study Section
Special Emphasis Panel (ZAR1-KM)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
7
Fiscal Year
2013
Total Cost
$200,583
Indirect Cost
$64,398

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Seol, Dongrim; Tochigi, Yuki; Bogner, Ashley M et al. (2018) Effects of knockout of the receptor for advanced glycation end-products on bone mineral density and synovitis in mice with intra-articular fractures. J Orthop Res 36:2439-2449
Thomas-Aitken, Holly D; Willey, Michael C; Goetz, Jessica E (2018) Joint contact stresses calculated for acetabular dysplasia patients using discrete element analysis are significantly influenced by the applied gait pattern. J Biomech 79:45-53
Coleman, Mitchell C; Goetz, Jessica E; Brouillette, Marc J et al. (2018) Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis. Sci Transl Med 10:
Townsend, Kevin C; Thomas-Aitken, Holly D; Rudert, M James et al. (2018) Discrete element analysis is a valid method for computing joint contact stress in the hip before and after acetabular fracture. J Biomech 67:9-17
Ding, Lei; Buckwalter, Joseph A; Martin, James A (2017) DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm 2017:2642549
Segal, Neil A; Frick, Eric; Duryea, Jeffrey et al. (2017) Comparison of tibiofemoral joint space width measurements from standing CT and fixed flexion radiography. J Orthop Res 35:1388-1395
Segal, Neil A; Bergin, John; Kern, Andrew et al. (2017) Test-retest reliability of tibiofemoral joint space width measurements made using a low-dose standing CT scanner. Skeletal Radiol 46:217-222
Dibbern, Kevin; Kempton, Laurence B; Higgins, Thomas F et al. (2017) Fractures of the tibial plateau involve similar energies as the tibial pilon but greater articular surface involvement. J Orthop Res 35:618-624
Kapitanov, Georgi I; Ayati, Bruce P; Martin, James A (2017) Modeling the effect of blunt impact on mitochondrial function in cartilage: implications for development of osteoarthritis. PeerJ 5:e3468
Martin, James A; Anderson, Donald D; Goetz, Jessica E et al. (2017) Complementary models reveal cellular responses to contact stresses that contribute to post-traumatic osteoarthritis. J Orthop Res 35:515-523

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