The Administrative, Biostatistics, and Investigator Support Core, directed by Drs. Joseph Buckwalter and Thomas Brown (CORT Program Director and Associate Director, respectively), will serve the three research projects and two research cores. Drs. Buckwalter and Brown will give the CORT direction, by coordinating all of the projects; they will also monitor budgets and ensure that investigators comply with University and NIH policies. They are committed to fostering interactions between projects and investigators, and between CORT bioengineers, basic scientists, imaging experts, and orthopaedic surgeons. A central goal for the Directors will be to spur translation of advances in basic science and bioengineering into advances in clinical treatments; reciprocally, the results of clinical studies will spur new basic research. The CORT investigators will consult with The University of Iowa Institute for Clinical and Translational Science (ICTS); Director, Gary Rosenthal MD, Associate Director for Biostatistics, Bridget Zimmerman PhD, to ensure their experimental designs meet rigorous biostatistical standards. The ICTS will support all projects and assist with performing statistical analysis, designing experiments, evaluating data collection, and submitting IRB applications so CORT repositories can collect biological specimens (e.g. joint fluid and serum). The Core will ensure that the External and Internal Advisory groups provide consultation and formally evaluate projects and cores, and identify underperforming endeavors as well as important new research directions. The CORT External and Internal Advisory Groups include internationally recognized experts: External Advisory Group Michael Conzemius, DVIVI, PhD (veterinary medicine and animal models of OA); Christopher Evans, PhD (animal models of arthritis, gene therapy, translational research); Jack Lewis, PhD (bioengineering, OA, joint injury and joint mechanics); Stefan Lohmander MD, PhD (joint injuries, biomarkers, clinical studies and posttraumatic OA); Martin Lotz, MD (joint biology, osteoarthritis, biologic treatments of OA), and Carol Vorwald, RN (layperson and retired nurse with longstanding commitment to OA patients); Internal Advisory Group Beverly Davidson, PhD (gene therapy), Joseph Reinhardt, PhD (imaging), and Douglas Spitz, PhD (free radical biology). Drs. Buckwalter and Brown will use the CORT Enrichment Program effectively and administer the Data-Sharing Plan and the Program for Pilot and Feasibility Projects. Lois Lembke (Administrative Assistant) has extensive experience administrating grants and departmental programs. She will assist Dr. Buckwalter with CORT administrative details, program coordination, budget monitoring, and evaluations of the projects and cores.

Public Health Relevance

The Administrative; Biostatistics and Investigator Support Core and the CORT Advisory Groups will provide oversight for the research projects and cores; solicit and evaluate new pilot and feasibility projects and stimulate development of new research directions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
5P50AR055533-08
Application #
8725047
Study Section
Special Emphasis Panel (ZAR1-KM)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
Fiscal Year
2014
Total Cost
$117,289
Indirect Cost
$39,442
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Yu, Y; Zheng, H; Buckwalter, J A et al. (2014) Single cell sorting identifies progenitor cell population from full thickness bovine articular cartilage. Osteoarthritis Cartilage 22:1318-26
Jang, Kee W; Buckwalter, Joseph A; Martin, James A (2014) Inhibition of cell-matrix adhesions prevents cartilage chondrocyte death following impact injury. J Orthop Res 32:448-54
Wang, Xiayi; Ayati, Bruce P; Brouillete, Marc J et al. (2014) Modeling and simulation of the effects of cyclic loading on articular cartilage lesion formation. Int J Numer Method Biomed Eng 30:927-41
Jang, Kee W; Ding, Lei; Seol, Dongrim et al. (2014) Low-intensity pulsed ultrasound promotes chondrogenic progenitor cell migration via focal adhesion kinase pathway. Ultrasound Med Biol 40:1177-86
Ding, Lei; Guo, Danping; Homandberg, Gene A et al. (2014) A single blunt impact on cartilage promotes fibronectin fragmentation and upregulates cartilage degrading stromelysin-1/matrix metalloproteinase-3 in a bovine ex vivo model. J Orthop Res 32:811-8
Anderson, Donald D; Thomas, Thaddeus P; Campos Marin, Ana et al. (2014) Computational techniques for the assessment of fracture repair. Injury 45 Suppl 2:S23-31
Diestelmeier, B W; Rudert, M J; Tochigi, Y et al. (2014) An instrumented pendulum system for measuring energy absorption during fracture insult to large animal joints in vivo. J Biomech Eng 136:064502
Brouillette, M J; Ramakrishnan, P S; Wagner, V M et al. (2014) Strain-dependent oxidant release in articular cartilage originates from mitochondria. Biomech Model Mechanobiol 13:565-72
Zhou, Cheng; Zheng, Hongjun; Seol, Dongrim et al. (2014) Gene expression profiles reveal that chondrogenic progenitor cells and synovial cells are closely related. J Orthop Res 32:981-8
Westerlind, Brian; Karam, Matthew; Anderson, Donald et al. (2014) A surgical skills training curriculum for PGY-1 residents: AAOS exhibit selection. J Bone Joint Surg Am 96:e140

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