Lateral compartment knee tibio-femoral radiographic osteoarthritis (TFROA) is associated with pain and disability, and studies of this form of knee OA are few. Recent studies find that race, pelvic anatomy and malalignment are associated with TFROA. Previous studies of knee OA have either combined medial and lateral compartment TFROA or have focused on medial compartment disease. We intend to elucidate the risk factors for and health outcomes of lateral compartment TFROA. Specifically we will (1) examine the association of lesions detected by MRI with lateral compartment TFROA;(2) examine known risk factors for medial compartment OA and their relation to prevalent and incident lateral compartment TFROA;(3) examine novel risk factors (e.g., hip and knee shape) that likely have compartment-specific effects and their relation to prevalent and incident lateral compartment TFROA;(4) examine the association of lateral compartment TFROA with incident functional impairment. We will use information collected in the Osteoarthritis Initiative (OAI) including longitudinal knee and hip x-ray and 3.0 Tesla MRI scans as well as detailed repeated risk factor, pain, and outcomes data. This proposed study will be one of the first done in a large, well-defined cohort with excellent follow-up, imaging and data collection of known and potential risk factors to focus specifically on lateral compartment TFROA.

Public Health Relevance

This research will examine the risk factors and health outcomes for a subset of knee osteoarthritis that is the lateral compartment of the knee using magnetic resonance imaging and regular x-rays. This will provide a greater understanding of the causes of functional impairment in this type of knee osteoarthritis and the progression to end stage of this disease. This will help to identify osteoarthritis patients who would be most likely to progress and to become disabled so that an effective treatment plan ca.0 be put into place to improve outcomes.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1-KM (M1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
San Francisco
United States
Zip Code
Joseph, Gabby B; McCulloch, Charles E; Nevitt, Michael C et al. (2017) Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X-ray, and MRI: Data from the osteoarthritis initiative. J Magn Reson Imaging :
Samaan, Michael A; Schwaiger, Benedikt J; Gallo, Matthew C et al. (2017) Joint Loading in the Sagittal Plane During Gait Is Associated With Hip Joint Abnormalities in Patients With Femoroacetabular Impingement. Am J Sports Med 45:810-818
Pedoia, Valentina; Samaan, Michael A; Inamdar, Gaurav et al. (2017) Study of the interactions between proximal femur 3d bone shape, cartilage health, and biomechanics in patients with hip Osteoarthritis. J Orthop Res :
Samaan, Michael A; Pedoia, Valentina; Zhang, Alan L et al. (2017) A novel mr-based method for detection of cartilage delamination in femoroacetabular impingement patients. J Orthop Res :
Samaan, Michael A; Schwaiger, Benedikt J; Gallo, Matthew C et al. (2017) Abnormal Joint Moment Distributions and Functional Performance During Sit-to-Stand in Femoroacetabular Impingement Patients. PM R 9:563-570
Jenkins, N W; Talbott, J F; Shah, V et al. (2017) [18F]-Sodium Fluoride PET MR-Based Localization and Quantification of Bone Turnover as a Biomarker for Facet Joint-Induced Disability. AJNR Am J Neuroradiol 38:2028-2031
Pedoia, Valentina; Su, Favian; Amano, Keiko et al. (2017) Analysis of the articular cartilage T1? and T2 relaxation times changes after ACL reconstruction in injured and contralateral knees and relationships with bone shape. J Orthop Res 35:707-717
Russell, Colin; Pedoia, Valentina; Majumdar, Sharmila et al. (2017) Composite metric R2 ?-?R1? (1/T2 ?-?1/T1? ) as a potential MR imaging biomarker associated with changes in pain after ACL reconstruction: A six-month follow-up. J Orthop Res 35:718-729
Joseph, Gabby B; McCulloch, Charles E; Nevitt, Michael C et al. (2017) Medial femur T2 Z-scores predict the probability of knee structural worsening over 4-8 years: Data from the osteoarthritis initiative. J Magn Reson Imaging 46:1128-1136
Pedoia, Valentina; Gallo, Matthew C; Souza, Richard B et al. (2017) Longitudinal study using voxel-based relaxometry: Association between cartilage T1? and T2 and patient reported outcome changes in hip osteoarthritis. J Magn Reson Imaging 45:1523-1533

Showing the most recent 10 out of 128 publications