Lateral compartment knee tibio-femoral radiographic osteoarthritis (TFROA) is associated with pain and disability, and studies of this form of knee OA are few. Recent studies find that race, pelvic anatomy and malalignment are associated with TFROA. Previous studies of knee OA have either combined medial and lateral compartment TFROA or have focused on medial compartment disease. We intend to elucidate the risk factors for and health outcomes of lateral compartment TFROA. Specifically we will (1) examine the association of lesions detected by MRI with lateral compartment TFROA;(2) examine known risk factors for medial compartment OA and their relation to prevalent and incident lateral compartment TFROA;(3) examine novel risk factors (e.g., hip and knee shape) that likely have compartment-specific effects and their relation to prevalent and incident lateral compartment TFROA;(4) examine the association of lateral compartment TFROA with incident functional impairment. We will use information collected in the Osteoarthritis Initiative (OAI) including longitudinal knee and hip x-ray and 3.0 Tesla MRI scans as well as detailed repeated risk factor, pain, and outcomes data. This proposed study will be one of the first done in a large, well-defined cohort with excellent follow-up, imaging and data collection of known and potential risk factors to focus specifically on lateral compartment TFROA.
This research will examine the risk factors and health outcomes for a subset of knee osteoarthritis that is the lateral compartment of the knee using magnetic resonance imaging and regular x-rays. This will provide a greater understanding of the causes of functional impairment in this type of knee osteoarthritis and the progression to end stage of this disease. This will help to identify osteoarthritis patients who would be most likely to progress and to become disabled so that an effective treatment plan ca.0 be put into place to improve outcomes.
|Lee, Sonia; Nardo, Lorenzo; Kumar, Deepak et al. (2015) Scoring hip osteoarthritis with MRI (SHOMRI): A whole joint osteoarthritis evaluation system. J Magn Reson Imaging 41:1549-57|
|Liebl, Hans; Heilmeier, Ursula; Lee, Sonia et al. (2015) In vitro assessment of knee MRI in the presence of metal implants comparing MAVRIC-SL and conventional fast spin echo sequences at 1.5 and 3 T field strength. J Magn Reson Imaging 41:1291-9|
|Subburaj, Karupppasamy; Souza, Richard B; Wyman, Bradley T et al. (2015) Changes in MR relaxation times of the meniscus with acute loading: An in vivo pilot study in knee osteoarthritis. J Magn Reson Imaging 41:536-43|
|Lansdown, Drew A; Zaid, Musa; Pedoia, Valentina et al. (2015) Reproducibility measurements of three methods for calculating in vivo MR-based knee kinematics. J Magn Reson Imaging 42:533-8|
|Serebrakian, Arman T; Poulos, Theresa; Liebl, Hans et al. (2015) Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative. J Magn Reson Imaging 41:1272-80|
|Chaudhari, Abhijit J; Leahy, Richard M; Wise, Barton L et al. (2014) Global point signature for shape analysis of carpal bones. Phys Med Biol 59:961-73|
|Katzman, Wendy B; Miller-Martinez, Dana; Marshall, Lynn M et al. (2014) Kyphosis and paraspinal muscle composition in older men: a cross-sectional study for the Osteoporotic Fractures in Men (MrOS) research group. BMC Musculoskelet Disord 15:19|
|Souza, R B; Kumar, D; Calixto, N et al. (2014) Response of knee cartilage T1rho and T2 relaxation times to in vivo mechanical loading in individuals with and without knee osteoarthritis. Osteoarthritis Cartilage 22:1367-76|
|Wise, Barton L; Parimi, Neeta; Zhang, Yuqing et al. (2014) Frailty and hip osteoarthritis in men in the MrOS cohort. J Gerontol A Biol Sci Med Sci 69:602-8|
|Boissonneault, A; Lynch, J A; Wise, B L et al. (2014) Association of hip and pelvic geometry with tibiofemoral osteoarthritis: multicenter osteoarthritis study (MOST). Osteoarthritis Cartilage 22:1129-35|
Showing the most recent 10 out of 35 publications