The Human Performance and Functional Testing Core is designed as both a service core and a development core. It will provide accurate and reliable research acquisition and processing services, specifically for projects #1 and #2 of the TOQIO CORT, as well as for other research teams at UCSF. It is also committed to the development of innovative monitoring of physical activity in persons with OA to evaluate the contribution of loading behaviors to cartilage health and disease. The Core will also serve as a valuable resource for multi-disciplinary pilot projects that emerge as part of the CORT mechanism. The overall objective of the Human Performance and Functional Testing Core is to provide comprehensive state-of- the-art three-dimensional motion analysis and functional testing facilities for experimental research projects and to develop new methods with improved technical capabilities. The Core is equipped with high-resolution motion analysis capabilities, including a 10-camera VICON optical motion capture system with capture frequency capabilities up to 1000 HZ and a cluster-based retro reflective marker set, 2 AMTI force platforms, and 2 high-resolution high-speed digital video cameras. The Core personnel are experts in the fields of motion analysis, sports medicine, and functional testing. The core will provide for accurate and reliable motion analysis acquisition and processing, as well as provide training and facilities for physical performance and functional testing procedures. Finally, the Core will provide resources for biosensor development for osteoarthritis (OA) research and personnel with extensive expertise in wireless sensor development and fabrication. The Core is ideally positioned with close access for all researchers and patients using this resource. The Core will be housed in the Human Performance Center on the Mission Bay Campus. This facility is a 900 square-foot laboratory located in the newly built Orthopaedic Institute at UCSF. Clinical recruitment will primarily be performed through orthopaedic clinics, which take place on the second floor of the Orthopaedic Institute., All Principle Investigators utilizing this Core have offices nearby, on or around the Mission Bay campus. Imaging facilities are also located in very close proximity to the Core, minimizing subject inconvenience, and facilitating ease of referral and data acquisition.

Public Health Relevance

OA is the second most common cause of permanent disability among subjects over the age of fifty. This proposal will evaluate the relationships between cartilage biochemical properties and functional mobility, including kinematics, kinetics and measures of physical performance.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZAR1-KM)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
San Francisco
United States
Zip Code
Lee, Sonia; Nardo, Lorenzo; Kumar, Deepak et al. (2015) Scoring hip osteoarthritis with MRI (SHOMRI): A whole joint osteoarthritis evaluation system. J Magn Reson Imaging 41:1549-57
Liebl, Hans; Heilmeier, Ursula; Lee, Sonia et al. (2015) In vitro assessment of knee MRI in the presence of metal implants comparing MAVRIC-SL and conventional fast spin echo sequences at 1.5 and 3 T field strength. J Magn Reson Imaging 41:1291-9
Subburaj, Karupppasamy; Souza, Richard B; Wyman, Bradley T et al. (2015) Changes in MR relaxation times of the meniscus with acute loading: An in vivo pilot study in knee osteoarthritis. J Magn Reson Imaging 41:536-43
Lansdown, Drew A; Zaid, Musa; Pedoia, Valentina et al. (2015) Reproducibility measurements of three methods for calculating in vivo MR-based knee kinematics. J Magn Reson Imaging 42:533-8
Serebrakian, Arman T; Poulos, Theresa; Liebl, Hans et al. (2015) Weight loss over 48 months is associated with reduced progression of cartilage T2 relaxation time values: data from the osteoarthritis initiative. J Magn Reson Imaging 41:1272-80
Chaudhari, Abhijit J; Leahy, Richard M; Wise, Barton L et al. (2014) Global point signature for shape analysis of carpal bones. Phys Med Biol 59:961-73
Katzman, Wendy B; Miller-Martinez, Dana; Marshall, Lynn M et al. (2014) Kyphosis and paraspinal muscle composition in older men: a cross-sectional study for the Osteoporotic Fractures in Men (MrOS) research group. BMC Musculoskelet Disord 15:19
Souza, R B; Kumar, D; Calixto, N et al. (2014) Response of knee cartilage T1rho and T2 relaxation times to in vivo mechanical loading in individuals with and without knee osteoarthritis. Osteoarthritis Cartilage 22:1367-76
Wise, Barton L; Parimi, Neeta; Zhang, Yuqing et al. (2014) Frailty and hip osteoarthritis in men in the MrOS cohort. J Gerontol A Biol Sci Med Sci 69:602-8
Boissonneault, A; Lynch, J A; Wise, B L et al. (2014) Association of hip and pelvic geometry with tibiofemoral osteoarthritis: multicenter osteoarthritis study (MOST). Osteoarthritis Cartilage 22:1129-35

Showing the most recent 10 out of 35 publications