The Clinical Core of this project will function to carefully characterize a cohort of subjects with scleroderma, drawn from two large referral centers, followed prospectively to link their clinical data, disease progression and severity with biologic mechanistic data.
The specific aims of this proposal are:
Aim 1 : To develop and maintain a clinical data repository of key clinical disease parameters in a prospectively followed cohort of subjects with scleroderma and match these clinical data with subject tissue and blood samples, which will be stored and maintained by the Clinical Core. The clinical core will also coordinate the collection of blood samples for preparation of RNA from peripheral blood mononuclear cells (PBMC) to be carried out by the microarray core. It will also coordinate the collection of skin biopsies for fixation and histological evaluation and for RNA preparation in coordination with the microarray core.
Aim 2 : To provide investigators in Projects 1, 2 and 3 with clinical data and statistical resources to perform analyses correlating gene array and biomarker data with matched clinical data collected longitudinally.
This project proposes to identify markers and predictors of clinical subsets and/or complications of scleroderma such as pulmonary hypertension, progression of skin involvement and development of interstitial lung disease. This biomarker identification will facilitate understanding of the causes of the disease and provide opportunities for intervention.
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|Gopal, Deepa M; Doldt, Bryan; Finch, Kim et al. (2014) Relation of novel echocardiographic measures to invasive hemodynamic assessment in scleroderma-associated pulmonary arterial hypertension. Arthritis Care Res (Hoboken) 66:1386-94|
|Christmann, Romy B; Mathes, Allison; Affandi, Alsya J et al. (2013) Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor *. Arthritis Rheum 65:1335-46|
|Hinchcliff, Monique; Huang, Chiang-Ching; Wood, Tammara A et al. (2013) Molecular signatures in skin associated with clinical improvement during mycophenolate treatment in systemic sclerosis. J Invest Dermatol 133:1979-89|
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