The goals of this supplement is to support two students to promote diversity under PA-18-586: Research Supplements to Promote Diversity in Health-Related Research. Both are PhD candidates in the Quantitative Biomedical Sciences (QBS) and Molecular and Cellular Biology (MCB) graduate programs at the Geisel School of Medicine and both students are working under the mentorship of Dr. Whitfield, the PI on the TGDI core. Both are implementing novel genomic analysis tools that will be made available in the core, as well as additional analysis methods and techniques. They are each using these methods in SSc focused projects that will probe the epigenome in SSc cells and tissues, and further analyze the microbiome in SSc tissue samples. The tools these students will implement in the TGDI core will also be applied to SSc samples as part of the CORT grant and provide novel insights into SSc pathogenesis.
The aims are to 1) provide epigenomic analysis of SSc samples using ATAC-seq, and 2) perform RNA- sequencing-derived metagenomics data through microbiome methods, multi-omics statistical methods, and functional networks modeling.

Public Health Relevance

This supplement will promote diversity in our CORT research program by supporting students from underrepresented minority populations as specified under PA-18-586: Research Supplements to Promote Diversity in Health-Related Research Each is using novel genomic and bioinformatic methods to probe the epigenome and microbiome in SSc. Accomplishing the aims will provide novel insights into SSc pathogenesis and help us develop novel treatments for this disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
3P50AR060780-07S1
Application #
9735705
Study Section
Special Emphasis Panel (ZAR1)
Program Officer
Wang, Yan Z
Project Start
2011-09-01
Project End
2022-08-31
Budget Start
2018-09-19
Budget End
2019-08-31
Support Year
7
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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Meiners, Silke; Evankovich, John; Mallampalli, Rama K (2018) The ubiquitin proteasome system as a potential therapeutic target for systemic sclerosis. Transl Res 198:17-28
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Cheong, Fei-Ying; Gower, Adam C; Farber, Harrison W (2017) Changes in gene expression profiles in patients with pulmonary arterial hypertension associated with scleroderma treated with tadalafil. Semin Arthritis Rheum 46:465-472
Yamashita, Takashi; Asano, Yoshihide; Taniguchi, Takashi et al. (2017) Glycyrrhizin Ameliorates Fibrosis, Vasculopathy, and Inflammation in Animal Models of Systemic Sclerosis. J Invest Dermatol 137:631-640

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