Incidence and prevalence of either radiographic or symptomatic osteoarthritis (OA) are much higher in women than men;however, the underlying causes for this sex difference in OA remain unknown. Several potential explanations have been proposed for the sex difference in OA, including differences in estrogen level, physical activity, and laxity or alignment, but each has only moderate supporting evidence, and none fully explains the observed sex differences. Recently, several investigators have proposed that aspects of bone shape are associated with an increased risk of incident OA and with severity of OA, based on anthropometric measures, cross-sectional findings, or in one case statistical shape modeling done on 24 knees. Our group demonstrated that several specific proximal femoral shapes, assessed by Active Shape Modeling (ASM), were associated with incident radiographic hip OA in elderly women. Others have also reported that ASM-based knee shape is associated with severity of radiographic knee OA. It is postulated that changes in bone shape occur prior to cartilage damage in the joint. In the proposed study, we will take the advantage of knee radiographs and magnetic resonance images (MRIs) collected annually for 5 years in the Osteoarthritis Initiative (OAI). We will measure femoral and tibial bone shape using an ASM method improved by our group. We will evaluate whether baseline bone shape is associated with incidence or progression of radiographic knee OA, pain and function and whether these associations differ by sex. We will apply group-based finite modeling methods to identify distinctive sub-groups that follow similar trajectories of bone shape change over time in women and men respectively and examine whether associations between various risk factors assessed at baseline (i.e., age, sex, body mass index, alignment, etc.) and membership of trajectories of bone shape differ by sex using a multinomial logistic regression model. Finally, we will evaluate the risk factors that determine sex-specific trajectories of bone shape change over time.

Public Health Relevance

To our knowledge, no study has yet described the trajectories of changes in bone shape over time, examined how those trajectories differ by sex, or identified the risk factors that determine sex-specific trajectories of bone shape change over time. In the proposed study, we will take the advantage of knee radiographs and magnetic resonance images collected annually for 5 years in the Osteoarthritis Initiative.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center (P50)
Project #
1P50AR063043-01
Application #
8367347
Study Section
Special Emphasis Panel (ZRG1-EMNR-Q (50))
Project Start
2012-09-12
Project End
2017-08-31
Budget Start
2012-09-12
Budget End
2013-08-31
Support Year
1
Fiscal Year
2012
Total Cost
$15,103
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Yao, W; Dai, W; Jiang, L et al. (2016) Sclerostin-antibody treatment of glucocorticoid-induced osteoporosis maintained bone mass and strength. Osteoporos Int 27:283-94
Skou, S T; Wise, B L; Lewis, C E et al. (2016) Muscle strength, physical performance and physical activity as predictors of future knee replacement: a prospective cohort study. Osteoarthritis Cartilage 24:1350-6
Wise, Barton L; Liu, Felix; Kritikos, Lisa et al. (2016) The association of distal femur and proximal tibia shape with sex: The Osteoarthritis Initiative. Semin Arthritis Rheum 46:20-6
Katzman, Wendy B; Parimi, Neeta; Mansoori, Ziba et al. (2016) Cross-sectional and Longitudinal Associations of Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Thoracic Kyphosis in Older Men and Women. Arthritis Care Res (Hoboken) :
Nelson, Amanda E; Golightly, Yvonne M; Renner, Jordan B et al. (2016) Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project. J Rheumatol 43:405-10
Kim, Jeehyoung; Bang, Heejung (2016) Three common misuses of P values. Dent Hypotheses 7:73-80
An, H; Marron, J S; Schwartz, T A et al. (2016) Novel statistical methodology reveals that hip shape is associated with incident radiographic hip osteoarthritis among African American women. Osteoarthritis Cartilage 24:640-6
Katzman, W B; Vittinghoff, E; Kado, D M et al. (2016) Thoracic kyphosis and rate of incident vertebral fractures: the Fracture Intervention Trial. Osteoporos Int 27:899-903
Mohan, Geetha; Lay, Evan Yu-An; Berka, Haley et al. (2016) A Novel Hybrid Compound LLP2A-Ale Both Prevented and Rescued the Osteoporotic Phenotype in a Mouse Model of Glucocorticoid-Induced Osteoporosis. Calcif Tissue Int :
Evans, Daniel S; Cailotto, Frederic; Parimi, Neeta et al. (2015) Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis. Ann Rheum Dis 74:1861-7

Showing the most recent 10 out of 48 publications