Abstract

This project will evaluate the effect, on cholesterol biosynthesis and atherosclerotic lesion formation, of a mixture of monacolins isolated from a yeast fermented rice compared to Lovastatin. This will be accomplished by measuring up-regulation of HMG-COA gene transcription in HEPG2 cell constructs containing a luciferase reporter gene. A second end point will be the formation of atherosclerotic lesions and measuring blood cholesterol levels in ApoE knockout mice. The final study will assay the bioavailability of the mixture of monacolins from red yeast rice and of pure Lovastatin in human volunteers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
5P50AT000151-04
Application #
6666250
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
$159,181
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Aziz, Nabil; Bonavida, Benjamin (2016) Activation of Natural Killer Cells by Probiotics. For Immunopathol Dis Therap 7:41-55
Sadava, David; Still, David W; Mudry, Ryan R et al. (2009) Effect of Ganoderma on drug-sensitive and multidrug-resistant small-cell lung carcinoma cells. Cancer Lett 277:182-9
Lu, Qing-Yi; Zhang, Yanjun; Wang, Yue et al. (2009) California Hass avocado: profiling of carotenoids, tocopherol, fatty acid, and fat content during maturation and from different growing areas. J Agric Food Chem 57:10408-13
Seeram, Navindra P; Zhang, Yanjun; McKeever, Rodney et al. (2008) Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. J Med Food 11:390-4
Mu, Li-Na; Cao, Wei; Zhang, Zuo-Feng et al. (2007) Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population. Cancer Causes Control 18:665-75
Woo, Ho-Hyung; Jeong, Byeong Ryong; Hirsch, Ann M et al. (2007) Characterization of Arabidopsis AtUGT85A and AtGUS gene families and their expression in rapidly dividing tissues. Genomics 90:143-53
Mu, L N; Cao, W; Zhang, Z F et al. (2007) Polymorphisms of 5,10-methylenetetralydrofolate reductase (MTHFR), fruit and vegetable intake, and the risk of stomach cancer. Biomarkers 12:61-75
Henning, Susanne M; Aronson, William; Niu, Yantao et al. (2006) Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption. J Nutr 136:1839-43
Gao, Kun; Xu, Anlong; Krul, Cyrille et al. (2006) Of the major phenolic acids formed during human microbial fermentation of tea, citrus, and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activity. J Nutr 136:52-7
Ikezoe, Takayuki; Yang, Yang; Saitoh, Takayuki et al. (2006) PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells. Int J Oncol 29:453-61

Showing the most recent 10 out of 64 publications