This application is for a renewal of our Dietary Supplement Research Center focusing on Botanicals. Our Botanical Research Center is a collaborative effort between the Pennington Biomedical Research Center of the Louisiana State University (LSU) System and the Biotechnology Center for Agriculture and the Environment of Rutgers University. The theme of the Center is "Botanicals and Metabolic Syndrome". The "metabolic syndrome" defines a human condition whose major features consist of obesity, insulin resistance, development of Type 2 diabetes and accelerated cardiovascular disease. As the prevalence of metabolic syndrome is reaching epidemic proportions worldwide, metabolic syndrome has been, and will continue to be, one of the most important public health problems facing society. Our Botanical Research Center will consist of three (3) research projects, an Integrative Biology Core, a Botanical core and an Administrative core. Each of the research projects will evaluate specific botanicals and assess the effect on cellular mechanisms proposed to contribute to the pathophysiology and development of the metabolic syndrome. Project 1 investigators will conduct studies to evaluate mechanisms of action by which selected extracts of Artemisia sp. modulate insulin receptor signaling and insulin sensitivity in both animal and in early phase human studies. Project 2 investigators will focus on mechanisms by which selected Artemisia sp. extracts and Hypericum perforatum L. (St. John's Wort) effect adipocyte development, adipokines, and insulin action. Project 3 investigators will evaluate how Asclepias incarnata modulates central mechanisms controlling appetite and energy expenditure as a means to improve overall energy balance and weight. We propose to use cutting-edge technologies that include metabolomic profiling, proteomic assessments, and bioaccessibility determinations. Thus, the scientific goal of our Center is to provide a comprehensive evaluation of specific, compelling hypotheses about the molecular, cellular and physiological mechanisms by which botanicals can modulate the development of the underlying pathophysiologic mechanisms of, and attenuate the development to, metabolic syndrome.

Public Health Relevance

Given the complications for metabolic syndrome, it is imperative that we implement effective strategies to improve the underlying pathophysiologic factors contributing to the condition. Our comprehensive study of botanicals and their effects to modulate pathologic processes leading to the development of the metabolic syndrome has great potential for being translated into practical benefits for human health.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
5P50AT002776-08
Application #
8326557
Study Section
Special Emphasis Panel (ZAT1-SM (19))
Program Officer
Hopp, Craig
Project Start
2005-04-01
Project End
2015-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
8
Fiscal Year
2012
Total Cost
$1,513,518
Indirect Cost
$327,174
Name
Lsu Pennington Biomedical Research Center
Department
None
Type
Organized Research Units
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808
Malina, Andrew; Bryant, Sherrisse K; Chang, Simon H et al. (2014) Capillary electrophoresis-based assay of phosphofructokinase-1. Anal Biochem 447:1-5
Cheng, Diana M; Pogrebnyak, Natalia; Kuhn, Peter et al. (2014) Development and phytochemical characterization of high polyphenol red lettuce with anti-diabetic properties. PLoS One 9:e91571
Cefalu, William T (2014) Paradoxical insights into whole body metabolic adaptations following SGLT2 inhibition. J Clin Invest 124:485-7
Graf, Brittany L; Poulev, Alexander; Kuhn, Peter et al. (2014) Quinoa seeds leach phytoecdysteroids and other compounds with anti-diabetic properties. Food Chem 163:178-85
Cheng, Diana M; Pogrebnyak, Natalia; Kuhn, Peter et al. (2014) Polyphenol-rich Rutgers Scarlet Lettuce improves glucose metabolism and liver lipid accumulation in diet-induced obese C57BL/6 mice. Nutrition 30:S52-8
Boudreau, Anik; Cheng, Diana M; Ruiz, Carmen et al. (2014) Screening native botanicals for bioactivity: an interdisciplinary approach. Nutrition 30:S11-6
Ribnicky, David M; Roopchand, Diana E; Poulev, Alexander et al. (2014) Artemisia dracunculus L. polyphenols complexed to soy protein show enhanced bioavailability and hypoglycemic activity in C57BL/6 mice. Nutrition 30:S4-10
Vance, Katie M; Ribnicky, David M; Rogers, Richard C et al. (2014) Artemisia santolinifolia enhances glutamatergic neurotransmission in the nucleus of the solitary tract. Neurosci Lett 582:115-9
Waterman, Carrie; Cheng, Diana M; Rojas-Silva, Patricio et al. (2014) Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. Phytochemistry 103:114-22
Henagan, Tara M; Lenard, Natalie R; Gettys, Thomas W et al. (2014) Dietary quercetin supplementation in mice increases skeletal muscle PGC1? expression, improves mitochondrial function and attenuates insulin resistance in a time-specific manner. PLoS One 9:e89365

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