Public Health Relevance

Given the paucity of data regarding safety and efficacy of botanicals, randomized trials with mechanistic aims are warranted. Before clinical studies can proceed, critical pre-clinical data addressing efficacy, safety and mechanisms are required. The studies will provide for a critical pre-clinical evaluation of botanicals to guide future studies designed to test feasible interventions for insulin resistance and metabolic syndrome.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
5P50AT002776-08
Application #
8381757
Study Section
Special Emphasis Panel (ZAT1-SM)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
8
Fiscal Year
2012
Total Cost
$172,513
Indirect Cost
$20,819
Name
Lsu Pennington Biomedical Research Center
Department
Type
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808
Knott, Eric J; Richard, Allison J; Mynatt, Randall L et al. (2017) Fenugreek supplementation during high-fat feeding improves specific markers of metabolic health. Sci Rep 7:12770
Cefalu, William T; Buse, John B; Tuomilehto, Jaakko et al. (2017) Response to Comment on Cefalu et al. Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors' Expert Forum. Diabetes Care 2016;39:1186-1201. Diabetes Care 40:e23-e24
Cefalu, William T; Boulton, Andrew J M; Tamborlane, William V et al. (2017) Diabetes Care: ""Taking It to the Limit One More Time"". Diabetes Care 40:3-6
Johnson, William D (2017) Author's response. Ann Allergy Asthma Immunol 118:525
Armas, Isabel; Pogrebnyak, Natalia; Raskin, Ilya (2017) A rapid and efficient in vitro regeneration system for lettuce (Lactuca sativa L.). Plant Methods 13:58
Rebello, Candida J; Greenway, Frank L; Johnson, William D et al. (2017) Fucoxanthin and Its Metabolite Fucoxanthinol Do Not Induce Browning in Human Adipocytes. J Agric Food Chem 65:10915-10924
Losso, Jack N; Finley, John W; Karki, Namrata et al. (2017) Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms. Am J Ther :
Cefalu, William T; Buse, John B; Tuomilehto, Jaakko et al. (2016) Update and Next Steps for Real-World Translation of Interventions for Type 2 Diabetes Prevention: Reflections From a Diabetes Care Editors' Expert Forum. Diabetes Care 39:1186-201
Cefalu, William T; Boulton, Andrew J M; Tamborlane, William V et al. (2016) Diabetes Care: ""Lagniappe"" and ""Seeing Is Believing""! Diabetes Care 39:1069-71
Moses, Robert G; Cefalu, William T (2016) Considerations in the Management of Gestational Diabetes Mellitus: ""You Are What Your Mother Ate!"". Diabetes Care 39:13-5

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