Public Health Relevance

Given the paucity of data regarding safety and efficacy of botanicals, randomized trials with mechanistic aims are warranted. Before clinical studies can proceed, critical pre-clinical data addressing efficacy, safety and mechanisms are required. The studies will provide for a critical pre-clinical evaluation of botanicals to guide future studies designed to test feasible interventions for insulin resistance and metabolic syndrome.

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
5P50AT002776-09
Application #
8543512
Study Section
Special Emphasis Panel (ZAT1-SM)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
9
Fiscal Year
2013
Total Cost
$182,016
Indirect Cost
$20,599
Name
Lsu Pennington Biomedical Research Center
Department
Type
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808
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Cefalu, William T; Boulton, Andrew J M; Tamborlane, William V et al. (2016) Building Momentum: Taking on the Real “Issues” of Diabetes Care! Diabetes Care 39:10-12
Johnson, William D; Romer, Jacob E (2016) Hypothesis Testing of Population Percentiles via the Wald Test with Bootstrap Variance Estimates. Open J Stat 6:14-24
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Obanda, Diana N; Ribnicky, David; Yu, Yongmei et al. (2016) An extract of Urtica dioica L. mitigates obesity induced insulin resistance in mice skeletal muscle via protein phosphatase 2A (PP2A). Sci Rep 6:22222
Cefalu, William T; Boulton, Andrew J M; Tamborlane, William V et al. (2016) Diabetes Care: "Lagniappe" and "Seeing Is Believing"! Diabetes Care 39:1069-71
Rebello, Candida J; O'Neil, Patrick M; Horn, Deborah B et al. (2016) Timing the discussion of antiobesity medications during obesity treatment. Obesity (Silver Spring) 24:2027-8
Rebello, Candida J; O'Neil, Carol E; Greenway, Frank L (2016) Dietary fiber and satiety: the effects of oats on satiety. Nutr Rev 74:131-47

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