Abstract

In preliminary studies we have identified botanicals that have favorable (selected Artemisia species) and unfavorable (St. John's Wort) effects on adipocyte development and function. The overall goal of project 2 is to study these specific botanicals to investigate the cellular mechanisms by which these botanicals regulate adipocyte function and influence whole body, insulin action. This goal is in harmony with the overall goal of the Center to provide a comprehensive evaluation of botanicals in addressing the pathophysiologic mechanisms that lead to the development of insulin resistance and the metabolic syndrome. Our studies will focus on adipocj/te development, adipokines, and insulin action. We will also fulfill the aims of the center by continuing active collaborations with project leaders and core participants. Additionally, we will perform studies to identify the bioactive constituents of Artemisia and SJW extracts, and to elucidate how these compounds effect adipocyte development and insulin.

Public Health Relevance

Significant advances towards understanding obesity, diabetes, and metabolic syndrome have been made by studying adipocyte development and fat cell function. Our studies focus on understanding the contribution of botanicals that negatively and positively affect adipocyte function. These studies will provide information of public health importance.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Complementary & Alternative Medicine (NCCAM)
Type
Specialized Center (P50)
Project #
5P50AT002776-09
Application #
8543514
Study Section
Special Emphasis Panel (ZAT1-SM)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
9
Fiscal Year
2013
Total Cost
$218,245
Indirect Cost
$49,026

  Institution

Name
Lsu Pennington Biomedical Research Center
Department
Type
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808

  Publications

Graf, Brittany L; Zhang, Li; Corradini, Maria G et al. (2018) Physicochemical differences between malanga (Xanthosoma sagittifolium) and potato (Solanum tuberosum) tubers are associated with differential effects on the gut microbiome. J Funct Foods 45:268-276
Kim, Youjin; Jaja-Chimedza, Asha; Merrill, Daniel et al. (2018) A 14-day repeated-dose oral toxicological evaluation of an isothiocyanate-enriched hydro-alcoholic extract from Moringa oleifera Lam. seeds in rats. Toxicol Rep 5:418-426
Rebello, Candida J; Nikonova, Elena V; Zhou, Sharon et al. (2018) Effect of Lorcaserin Alone and in Combination with Phentermine on Food Cravings After 12-Week Treatment: A Randomized Substudy. Obesity (Silver Spring) 26:332-339
Forney, Laura A; Lenard, Natalie R; Stewart, Laura K et al. (2018) Dietary Quercetin Attenuates Adipose Tissue Expansion and Inflammation and Alters Adipocyte Morphology in a Tissue-Specific Manner. Int J Mol Sci 19:
Losso, Jack N; Finley, John W; Karki, Namrata et al. (2018) Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms. Am J Ther 25:e194-e201
Yu, Yongmei; Mendoza, Tamra M; Ribnicky, David M et al. (2018) An Extract of Russian Tarragon Prevents Obesity-Related Ectopic Lipid Accumulation. Mol Nutr Food Res 62:e1700856
Zhang, Li; Carmody, Rachel N; Kalariya, Hetal M et al. (2018) Grape proanthocyanidin-induced intestinal bloom of Akkermansia muciniphila is dependent on its baseline abundance and precedes activation of host genes related to metabolic health. J Nutr Biochem 56:142-151
Boudreau, Anik; Fuller, Scott; Ribnicky, David M et al. (2018) Groundsel Bush (Baccharis halimifolia) Extract Promotes Adipocyte Differentiation In Vitro and Increases Adiponectin Expression in Mature Adipocytes. Biology (Basel) 7:
Bruce-Keller, Annadora J; Salbaum, J Michael; Berthoud, Hans-Rudolf (2018) Harnessing Gut Microbes for Mental Health: Getting From Here to There. Biol Psychiatry 83:214-223
Hsia, Daniel S; Grove, Owen; Cefalu, William T (2017) An update on sodium-glucose co-transporter-2 inhibitors for the treatment of diabetes mellitus. Curr Opin Endocrinol Diabetes Obes 24:73-79

Showing the most recent 10 out of 174 publications