The principal source of proposals for SPORE Developmental Research funding is an annual request for applications to all investigators in the institution, explaining the SPORE program goals and soliciting proposals for innovative projects. This RFA is publicized widely throughout the departments and centers of the College. Baylor's solid base of basic researchers in a variety of biological disciplines offers a wide field of potential collaborations - indeed, this was one of the chief attractions leading to the group's move from San Antonio in 1999. Our RFAs for developmental proposals have yielded applications representing many departments and centers and including internationally recognized laboratories. In addition, a portion of the SPORE developmental funds is reserved for possible projects of exceptional promise which may arise in mid-year. Such projects would normally be identified by the SPORE Executive Committee and Internal Advisory Committee. Indeed, the Executive Committee may take a direct role in the preparation of potential projects, seeking opportunities to be exploited and encouraging investigators to organize such projects and carry out any necessary pilot work to give an indication of the concept's feasibility. Thus we can take advantage of opportunities that develop at any time during the year, because of new findings, new technologies and unique reagents, or unexpected collaborative possibilities. This flexibility has more than once allowed us to proceed rapidly to translational development of a new discovery.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA058183-17
Application #
8208777
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2010-12-01
Budget End
2011-11-30
Support Year
17
Fiscal Year
2011
Total Cost
$78,223
Indirect Cost
Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Yu, L; Liang, Y; Cao, X et al. (2017) Identification of MYST3 as a novel epigenetic activator of ER? frequently amplified in breast cancer. Oncogene 36:2910-2918
Holloway, Kimberly R; Sinha, Vidya C; Bu, Wen et al. (2016) Targeting Oncogenes into a Defined Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype. Int J Biol Sci 12:381-8
Malorni, Luca; Giuliano, Mario; Migliaccio, Ilenia et al. (2016) Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance. Mol Cancer Res 14:470-81
Fu, Xiaoyong; Jeselsohn, Rinath; Pereira, Resel et al. (2016) FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer. Proc Natl Acad Sci U S A 113:E6600-E6609
Erdem, Cemal; Nagle, Alison M; Casa, Angelo J et al. (2016) Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways. Mol Cell Proteomics 15:3045-57
Chaluvally-Raghavan, Pradeep; Jeong, Kang Jin; Pradeep, Sunila et al. (2016) Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer. Cell Rep 15:1493-1504
Dobrolecki, Lacey E; Airhart, Susie D; Alferez, Denis G et al. (2016) Patient-derived xenograft (PDX) models in basic and translational breast cancer research. Cancer Metastasis Rev 35:547-573
Shi, Aiping; Dong, Jie; Hilsenbeck, Susan et al. (2015) The Status of STAT3 and STAT5 in Human Breast Atypical Ductal Hyperplasia. PLoS One 10:e0132214
Canfield, Kaleigh; Li, Jiaqi; Wilkins, Owen M et al. (2015) Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells. Cell Cycle 14:648-55
Sine, Jessica; Urban, Cordula; Thayer, Derek et al. (2015) Photo activation of HPPH encapsulated in ""Pocket"" liposomes triggers multiple drug release and tumor cell killing in mouse breast cancer xenografts. Int J Nanomedicine 10:125-45

Showing the most recent 10 out of 295 publications