Abstract

This application for continuation of the Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer at the Johns Hopkins Medical Institutions supports a highly interactive, multidisciplinary, and interinstitutional program. Eight research projects within four research programs, four cores, a career development and a research developmental program are proposed to further our translational research in colorectal and pancreatic cancer. Research Program 1: Applied Cancer Genetics (0012, Diagnosis and prognosis of human cancers through molecular genetic analyses, Dr. Kenneth Kinzler; 0002, New genetic clues in pancreatic cancer, Dr. Scott Kern). Program 2: Markers of Tumorigenesis (0013, Components of early and late pancreatic neoplasia, Dr. Scott Kern; 0008, Screening markers for high pancreatic cancer susceptibility, Dr. Michael Goggins). Program 3: Assessment of Familial Risk- (0014, Risk prediction in familial colorectal cancer, Dr. Giovanni Parmigiani; 0011, Markers for risk in familial pancreatic cancer, Dr. Ralph Hruban). Program 4: Therapeutic Directions (0015, Chemoprevention of human colorectal tumors, Dr. David Huso; 0016, Integration of chemotherapy with vaccination in metastatic pancreatic cancer, Dr. Elizabeth Jaffee). The cores support the research programs ( 9002, Human Tissue Research and Logistics, Dr. Elizabeth Montgomery; 9003, Familial Cancer Registries, Dr. Frank Giardiello; 9004, Statistics/Bioinformatics, Dr. Steven Goodman. The Career Development Program (Dr. Scott Kern) aids the emergence of new investigators and the Research Developmental Program (Dr. Bert Vogelstein) provides rapid funding of innovative directions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
3P50CA062924-13S3
Application #
7285071
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Agarwal, Rajeev K
Project Start
1993-09-30
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
13
Fiscal Year
2006
Total Cost
$250,000
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Kuboki, Yuko; Fischer, Catherine G; Beleva Guthrie, Violeta et al. (2018) Single-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions. J Pathol :
Zhang, Jiajia; Quadri, Shafat; Wolfgang, Christopher L et al. (2018) New Development of Biomarkers for Gastrointestinal Cancers: From Neoplastic Cells to Tumor Microenvironment. Biomedicines 6:
Hata, Tatsuo; Suenaga, Masaya; Marchionni, Luigi et al. (2018) Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia. Am J Pathol 188:1723-1733
Noë, Michaël; Rezaee, Neda; Asrani, Kaushal et al. (2018) Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology. Am J Pathol 188:1530-1535
Schunke, Kathryn J; Rosati, Lauren M; Zahurak, Marianna et al. (2018) Long-term analysis of 2 prospective studies that incorporate mitomycin C into an adjuvant chemoradiation regimen for pancreatic and periampullary cancers. Adv Radiat Oncol 3:42-51
Zhang, Jiajia; Wolfgang, Christopher L; Zheng, Lei (2018) Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer. Cancers (Basel) 10:
Dejea, Christine M; Fathi, Payam; Craig, John M et al. (2018) Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria. Science 359:592-597
Staedtke, Verena; Bai, Ren-Yuan; Kim, Kibem et al. (2018) Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome. Nature 564:273-277
Deng, Yang; Tu, Huakang; Pierzynski, Jeanne A et al. (2018) Determinants and prognostic value of quality of life in patients with pancreatic ductal adenocarcinoma. Eur J Cancer 92:20-32
Tamura, Koji; Yu, Jun; Hata, Tatsuo et al. (2018) Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer. Proc Natl Acad Sci U S A 115:4767-4772

Showing the most recent 10 out of 883 publications