This application for continuation of the Specialized Program of Research Excellence (SPORE) in Gastrointestinal Cancer at the Johns Hopkins Medical Institutions supports a highly interactive, multidisciplinary, and inter-institutional program. Seven research projects within three research programs, four cores, a career development and a research developmental program are proposed to extend our translational research in colorectal and pancreatic cancer. Research Program 1: Fundamentals for individualizing patient management (Project 1A, Early detection of human colorectal and pancreatic cancer, Drs. Kinzler and Giardiello;1B, Pharmacodiagnostics through molecular clues, Drs. Kern and Laheru). Program 2: Developing and understanding novel therapeutics (2A, Antigen-specific monitoring and therapy in pancreatic Ca, Drs. Jaffee and Laheru;2B, Optimizing and monitoring C. novvi therapy of metastatic colorectal Ca, Drs. Zhou and Diaz). Program 3: Managing and identifying pancreatic neoplasia in the curable stage (3A, Markers for risk in familial pancreatic cancer Hruban, Klein, and Goggins;3B, Screening markers for persons with high pancreatic cancer susceptibility, Drs. Goggins and Hruban;3C, Fundamentals of early and variant pancreatic neoplasia, Drs. Maitra, Kern, and Hruban). The cores support the research programs (Core 1, Administration and Communication, Dr. Scott Kern;2, Human Tissue Research and Logistics, Dr. Ralph Hruban;3, Familial Cancer Registries, Dr. Frank Giardiello;4, Statistics/Bioinformatics, Dr. Steven Goodman. The Career Development Program (Dr. Scott Kern) aids the emergence of new investigators and the Research Developmental Program (Dr. Bert Vogelstein) provides rapid funding of innovative directions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA062924-18
Application #
8096775
Study Section
Special Emphasis Panel (ZCA1-GRB-I (J1))
Program Officer
Agarwal, Rajeev K
Project Start
2007-08-29
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
18
Fiscal Year
2011
Total Cost
$2,185,000
Indirect Cost
Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Wood, Laura D; Noë, Michaël; Hackeng, Wenzel et al. (2017) Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas. Virchows Arch 470:391-400
Luchini, Claudio; Robertson, Scott A; Hong, Seung-Mo et al. (2017) PBRM1 loss is a late event during the development of cholangiocarcinoma. Histopathology 71:375-382
Murphy, Adrian G; Foley, Kelly; Rucki, Agnieszka A et al. (2017) Stromal Annexin A2 expression is predictive of decreased survival in pancreatic cancer. Oncotarget 8:106405-106414
Rucki, Agnieszka A; Foley, Kelly; Zhang, Pingbo et al. (2017) Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer. Cancer Res 77:41-52
Jinawath, Natini; Shiao, Meng-Shin; Norris, Alexis et al. (2017) Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas. Genes Chromosomes Cancer 56:427-435
Tsujikawa, Takahiro; Kumar, Sushil; Borkar, Rohan N et al. (2017) Quantitative Multiplex Immunohistochemistry Reveals Myeloid-Inflamed Tumor-Immune Complexity Associated with Poor Prognosis. Cell Rep 19:203-217
Suenaga, Masaya; Sadakari, Yoshihiko; Almario, Jose Alejandro et al. (2017) Using an endoscopic distal cap to collect pancreatic fluid from the ampulla (with video). Gastrointest Endosc 86:1152-1156.e2
Todoric, Jelena; Antonucci, Laura; Di Caro, Giuseppe et al. (2017) Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell 32:824-839.e8
Mattox, Austin K; Wang, Yuxuan; Springer, Simeon et al. (2017) Bisulfite-converted duplexes for the strand-specific detection and quantification of rare mutations. Proc Natl Acad Sci U S A 114:4733-4738
Johnson 3rd, Burles A; Yarchoan, Mark; Lee, Valerie et al. (2017) Strategies for Increasing Pancreatic Tumor Immunogenicity. Clin Cancer Res 23:1656-1669

Showing the most recent 10 out of 843 publications