Introduction: The Molecular Imaging Specialized Resource supports in-vivo microPET, microCT, optical bioluminescent and fluorescent imaging and ex-vivo autoradiography for ICMIC research. The MISR was started as a Department of Energy facility in 1990 with a dedicated animal PET system. In 1997, microPET was developed at UCLA and the prototype system was used for rodent imaging until 2003. Over time, we added a microCT system in 1999 and upgraded it in 2003, added commercial microPET systems (P4: 2000-2007, Focus 220: 2003, Inveon DPET: 2008), optical imaging systems (3 IVIS 100 systems and a CRi Maestro), along with autoradiography and cryostat systems. We constantly evaluate new imaging technology and update systems when there is value and need for improved imaging devices. Since its inception in 1997, we have conducted over 26,000 microPET imaging experiments. Since previous ICMIC cycle began in 2005, the center has averaged just over 12,000 imaging studies of various types each year, roughly one thousand studies per month. The Molecular Imaging Shared Resource is essential for all four of the proposed ICMIC research projects and all four of the developmental fund projects, as well as future projects that require monitoring in-vivo measurements of metabolic function. All PET, CT, optical and autoradiography described in this proposal will make use of the MISR, making this resource central to the entire ICMIC program. The resource is intertwined with the production of imaging probes produced by the Cyclotron and Radiochemistry Specialized Resource directed by Dr. Satyamurthy and with the Quantitative Image Analysis Specialized Resource (QIASR) directed by Dr. Huang, which provides data analysis services to our investigators. The QIASR is especially linked with the MISR, since there is shared responsibility for managing the images and associated database information, image archival and website support of reports and usage information. Dr. Stout, who manages the MISR imaging facility, has worked closely with Drs. Huang and Satyamuthy for over 20 years and meets frequently with both to share information and maintain close coordination of efforts.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA086306-14
Application #
8541716
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
14
Fiscal Year
2013
Total Cost
$141,628
Indirect Cost
$58,328
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Jiao, Jing; Ishikawa, Tomo-O; Dumlao, Darren S et al. (2014) Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. Mol Cancer Res 12:1677-88
Jiao, Jing; Mikulec, Carol; Ishikawa, Tomo-o et al. (2014) Cell-type-specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis 35:1310-9
Shurell, Elizabeth; Tran, Linh M; Nakashima, Jonathan et al. (2014) Gender dimorphism and age of onset in malignant peripheral nerve sheath tumor preclinical models and human patients. BMC Cancer 14:827
Mongini, Patricia K A; Kramer, Jill M; Ishikawa, Tomo-O et al. (2014) Candidate chromosome 1 disease susceptibility genes for Sjogren's syndrome xerostomia are narrowed by novel NOD.B10 congenic mice. Clin Immunol 153:79-90
Wilks, Moses Q; Knowles, Scott M; Wu, Anna M et al. (2014) Improved modeling of in vivo kinetics of slowly diffusing radiotracers for tumor imaging. J Nucl Med 55:1539-44
Schwarzenberg, Johannes; Czernin, Johannes; Cloughesy, Timothy F et al. (2014) Treatment response evaluation using 18F-FDOPA PET in patients with recurrent malignant glioma on bevacizumab therapy. Clin Cancer Res 20:3550-9
Wardak, Mirwais; Schiepers, Christiaan; Cloughesy, Timothy F et al. (2014) ¹?F-FLT ???and ¹?F-FDOPA PET kinetics in recurrent brain tumors. Eur J Nucl Med Mol Imaging 41:1199-209
Nathanson, David A; Armijo, Amanda L; Tom, Michelle et al. (2014) Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J Exp Med 211:473-86
Hirata, Kenji; Kobayashi, Kentaro; Wong, Koon-Pong et al. (2014) A semi-automated technique determining the liver standardized uptake value reference for tumor delineation in FDG PET-CT. PLoS One 9:e105682
Escuin-Ordinas, Helena; Atefi, Mohammad; Fu, Yong et al. (2014) COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors. Mol Oncol 8:250-60

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