Overview of the organizational structure of the UCLA ICMIC (Figure 1). Dr. Herschman is Principal Investigator of the UCLA ICMIC, Dr. Phelps will serve functionally as Co-Principal investigator, although this is no longer a recognized NIH title. Drs. Herschman and Phelps are supported by a budgeted Administrative Component that include secretarial, financial and grants preparation assistance. The ICMIC program has four Research Component projects, headed by Drs Ribas, Radu, Hong Wu and Herschman. There are three Specialized Resources. The Cyclotron and Radiochemistry Specialized Resource, directed by Dr. Satyamuthy, provides positron-emitting radiotracers for ICMIC studies. The Molecular Imaging Specialized Resource, directed by Dr. Stout, provides access to molecular imaging instrumentation as well as expertise, instruction and technical assistance in their utilization. The Quantitative Image Analysis Specialized Resource, directed by Dr Henry Huang, provides expert assistance in image interpretation and quantization, data storage and retrieval, and modeling of microPET data. The Specialized Resources provide imaging reagents, instrumentation, technical assistance, instruction and intellectual insight in support of the research efforts of the Research Component Projects, the Developmental Fund Projects and the Career Development recipients. The Developmental Fund program supports a steady state of four Developmental Projects, usually of two years duration. We try to stagger the projects so that each year there will be a competition for two new Developmental Fund Projects. However, second year applications are in competition with new applications, and on occasion we will terminate a Developmental Project at the end of the flrst year and initiate three new Developmental Projects in one year. Our Career Development Component provides individual stipends to candidates who want to integrate molecular imaging into their research programs- Career Development funds are recompeted annually. Drs. Herschman and Phelps are advised quarteriy by the Internal Advisory Board (Section B.4), which is made up of past and present ICMIC project directors, and annually by members of the External Advisory Board.

National Institute of Health (NIH)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Jiao, Jing; Ishikawa, Tomo-O; Dumlao, Darren S et al. (2014) Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. Mol Cancer Res 12:1677-88
Jiao, Jing; Mikulec, Carol; Ishikawa, Tomo-o et al. (2014) Cell-type-specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis 35:1310-9
Shurell, Elizabeth; Tran, Linh M; Nakashima, Jonathan et al. (2014) Gender dimorphism and age of onset in malignant peripheral nerve sheath tumor preclinical models and human patients. BMC Cancer 14:827
Mongini, Patricia K A; Kramer, Jill M; Ishikawa, Tomo-O et al. (2014) Candidate chromosome 1 disease susceptibility genes for Sjogren's syndrome xerostomia are narrowed by novel NOD.B10 congenic mice. Clin Immunol 153:79-90
Wilks, Moses Q; Knowles, Scott M; Wu, Anna M et al. (2014) Improved modeling of in vivo kinetics of slowly diffusing radiotracers for tumor imaging. J Nucl Med 55:1539-44
Schwarzenberg, Johannes; Czernin, Johannes; Cloughesy, Timothy F et al. (2014) Treatment response evaluation using 18F-FDOPA PET in patients with recurrent malignant glioma on bevacizumab therapy. Clin Cancer Res 20:3550-9
Wardak, Mirwais; Schiepers, Christiaan; Cloughesy, Timothy F et al. (2014) ¹?F-FLT ???and ¹?F-FDOPA PET kinetics in recurrent brain tumors. Eur J Nucl Med Mol Imaging 41:1199-209
Nathanson, David A; Armijo, Amanda L; Tom, Michelle et al. (2014) Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J Exp Med 211:473-86
Hirata, Kenji; Kobayashi, Kentaro; Wong, Koon-Pong et al. (2014) A semi-automated technique determining the liver standardized uptake value reference for tumor delineation in FDG PET-CT. PLoS One 9:e105682
Escuin-Ordinas, Helena; Atefi, Mohammad; Fu, Yong et al. (2014) COX-2 inhibition prevents the appearance of cutaneous squamous cell carcinomas accelerated by BRAF inhibitors. Mol Oncol 8:250-60

Showing the most recent 10 out of 184 publications