The goal of this Career Developmental Program (CDP) is to support the multi-disciplinary training of junior investigators past their post-doctoral career who have an outstanding academic track record and wish to engage in molecular imaging research to ultimately establish an independent research program. Funds are requested to support two trainees per year. The CDP emphasizes the cross-training of basic (PhD) and/or clinical [MD or MD/PhD] and/or clinical (MD or MD/PhD) scientists in the principles of molecular techniques to answer basic science questions through in vivo imaging. Overall, we believe that the development, validation, and application of novel imaging techniques (e.g. receptor mapping, imaging of should further enhance tour understanding of disease mechanisms and go hand in hand with the development of molecular medicine. The program consists of didactic lectures, laboratory exercises, individual research projects and a mentorship program. Trainees who successfully complete the program are excellent candidates for leadership positions in Molecular Imaging Programs. The primary consists of 14 senior scientists with extensive experience in training. The faculty has over 35 extramural research grants including over 15 NCI grants that directly addresses issues of cancer diagnosis and therapy using novel imaging approaches. The faculty has supervised over 300 pre and postdoctoral fellows and over junior investigators in various aspects of basic and clinical research. We have also developed successful that, with our current faculty, facilities, scape of supported research, and past accomplishments, we an achieve our state goal of providing highly qualified MD and PhD scientists for the biomedical research community.
| Dubach, J Matthew; Kim, Eunha; Yang, Katherine et al. (2017) Quantitating drug-target engagement in single cells in vitro and in vivo. Nat Chem Biol 13:168-173 |
| Vinegoni, Claudio; Fumene Feruglio, Paolo; Brand, Christian et al. (2017) Measurement of drug-target engagement in live cells by two-photon fluorescence anisotropy imaging. Nat Protoc 12:1472-1497 |
| Iaconelli, Jonathan; Lalonde, Jasmin; Watmuff, Bradley et al. (2017) Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells. ACS Chem Biol 12:2139-2148 |
| Arlauckas, Sean P; Garris, Christopher S; Kohler, Rainer H et al. (2017) In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sci Transl Med 9: |
| Miller, Miles A; Weissleder, Ralph (2017) Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior. Adv Drug Deliv Rev 113:61-86 |
| Engblom, Camilla; Pfirschke, Christina; Zilionis, Rapolas et al. (2017) Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science 358: |
| Miller, Miles A; Askevold, Bjorn; Mikula, Hannes et al. (2017) Nano-palladium is a cellular catalyst for in vivo chemistry. Nat Commun 8:15906 |
| Roy, Jeremy; Kim, Bongki; Hill, Eric et al. (2016) Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nat Commun 7:10666 |
| Pfirschke, Christina; Engblom, Camilla; Rickelt, Steffen et al. (2016) Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity 44:343-54 |
| Wu, Juwell W; Turcotte, Raphaël; Alt, Clemens et al. (2016) Defining Clonal Color in Fluorescent Multi-Clonal Tracking. Sci Rep 6:24303 |
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