The overall goal of this ICMIC is to develop and use advanced imaging approaches to gain in-depth knowledge of critical cancer targets, pathways and cellular function. This information will ultimately be used to identify new therapeutic points of attack and to guide clinical trials with prominent drug development candidates. To this end, we have brought together a multi-disciplinary team of basic and clinical investigators who will function as a single intellectual unit in the development of imaging approaches for targeted therapeutic applications. Project 1 (Weissleder) will focus on the development of effective new imaging agents for intracellular cancer targets using a novel bioorthogonal chemistry. Project 2 (Mazitschek, Clardy) will develop and test imaging approaches for different histone deacetylase (HDAC), enzymes associated with epigenetic gene regulation and which are strongly implicated in cancer. Project 3 (Lin, Scadden) will harness vanguard technologies to image and better understand the clonal fates of tumor cells and their associated stromal cells. Project 4 (Pittet) will investigate tumor-associated immune responses, and the effects of therapies on these responses. There will be two Developmental Fund Projects per year, the aims of which will be to attract new investigators to the P50, stimulate creative high-impact research, rapidly test new ideas, and fund promising collaborative work. The highly effective Career Development Program will continue to provide new junior investigators with the necessary multidisciplinary skills for a successful research career in cancer imaging. The above projects and programs will be facilitated by state-of-the art, highly innovative Specialized Resources in Chemistry (Hilderbrand), and in Mouse Imaging and Analysis (Nahrendorf). Fiscal management and oversight, as well as IT and statistical support will be provided by an Administration, Statistics and IT Core (Weissleder). Together, these ICMIC components will work synergistically to a) incorporate molecular imaging into pioneering cancer research at Harvard/MGH, and b) encourage the translation of molecular imaging to the practice of cancer diagnosis, management and therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA086355-13
Application #
8332778
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (M1))
Program Officer
Menkens, Anne E
Project Start
2000-08-09
Project End
2016-06-30
Budget Start
2012-08-22
Budget End
2013-06-30
Support Year
13
Fiscal Year
2012
Total Cost
$1,358,452
Indirect Cost
$583,488
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Pfirschke, Christina; Engblom, Camilla; Rickelt, Steffen et al. (2016) Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity 44:343-54
Ghosh, Balaram; Zhao, Wen-Ning; Reis, Surya A et al. (2016) Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation. Bioorg Med Chem Lett 26:1265-71
Roy, Jeremy; Kim, Bongki; Hill, Eric et al. (2016) Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging. Nat Commun 7:10666
Wu, Juwell W; Turcotte, Raphaël; Alt, Clemens et al. (2016) Defining Clonal Color in Fluorescent Multi-Clonal Tracking. Sci Rep 6:24303
Reis, Surya A; Ghosh, Balaram; Hendricks, J Adam et al. (2016) Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol 12:317-23
Pucci, Ferdinando; Rickelt, Steffen; Newton, Andita P et al. (2016) PF4 Promotes Platelet Production and Lung Cancer Growth. Cell Rep 17:1764-1772
Miller, Miles A; Weissleder, Ralph (2016) Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior. Adv Drug Deliv Rev :
Vinegoni, Claudio; Dubach, John M; Feruglio, Paolo Fumene et al. (2016) Two-photon Fluorescence Anisotropy Microscopy for Imaging and Direct Measurement of Intracellular Drug Target Engagement. IEEE J Sel Top Quantum Electron 22:
Meimetis, Labros G; Boros, Eszter; Carlson, Jonathan C et al. (2016) Bioorthogonal Fluorophore Linked DFO-Technology Enabling Facile Chelator Quantification and Multimodal Imaging of Antibodies. Bioconjug Chem 27:257-63
Pucci, Ferdinando; Garris, Christopher; Lai, Charles P et al. (2016) SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science 352:242-6

Showing the most recent 10 out of 309 publications