This application represents a renewal application for a Specialized Program of Research Excellence (SPORE) in Prostate Cancer from the Prostate Cancer Program of Dana-Farber/Harvard Cancer Center (DF/HCC). The DF/HCC Prostate Cancer SPORE has been continuously funded since 2002. DF/HCC is comprised of the following institutions: Dana-Farber Cancer Institute;Harvard Medical School;Harvard School of Public Health;Beth Israel-Deaconess Medical Center;Brigham and Women's Hospital;Massachusetts General Hospital;and Children's Hospital of Boston. In addition to the institutions in the DF/HCC, the Broad Institute is a collaborating institution in this grant. The DF/HCC Prostate Cancer SPORE has its administrative base at the DFCI. Dr. Philip Kantoff, who has led the DF/HCC Prostate Cancer Program and SPORE since their inception, is joined by Co-Directors Dr. William Hahn, a laboratory scientist at DFCI, and Dr. Steven Balk, a laboratory scientist at BIDMC. Dr. Kantoff reports directly to Dr. Edward Benz, Director of DF/HCC and President of DFCI. The DF/HCC Prostate Cancer SPORE has a broad and deep talent base and there is extensive institutional commitment. We take advantage of a large patient population and cutting edge technologies that are available to us as part of DF/HCC. We propose 5 Projects which address critical problems in prostate cancer and have translational components including 1) understanding the mechanism by which obesity impacts prostate cancer mortality 2) dissecting the clinical heterogeneity of Gleason 7 prostate cancer 3) elucidating the importance of the EZH2 signaling pathway 4) understanding the role that genomic change has on resistance to androgen deprivation therapy and on aggressive prostate cancer and finally 5) understanding the mechanism that underlie resistance to secondary forms of hormonal therapy. The five projects are supported by three Cores, an Administrative, a Biostatistics and Computional Biology and a Tissue and Pathology Core. We also have a highly successful Career Development Progam that selects talented phycian scientists and mentors them to independence and a Developmental Projects Program that generates new ideas for the SPORE in the future.
This SPORE is focused on several important themes in prostate cancer 1) the identification of lethal prostate cancer using genetic and genomic approaches 2) understanding the role of metabolism on the development of lethal prostate cancer, and understanding the mechanism of primary and secondary resistance to hormanal therapy and finally elucidating new targets for therpay in men with advanced disease.
|Chen, Eddy J; Sowalsky, Adam G; Gao, Shuai et al. (2015) Abiraterone treatment in castration-resistant prostate cancer selects for progesterone responsive mutant androgen receptors. Clin Cancer Res 21:1273-80|
|Labbé, D P; Zadra, G; Ebot, E M et al. (2015) Role of diet in prostate cancer: the epigenetic link. Oncogene 34:4683-91|
|Sowalsky, Adam G; Xia, Zheng; Wang, Liguo et al. (2015) Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer. Mol Cancer Res 13:98-106|
|Penney, Kathryn L; Sinnott, Jennifer A; Tyekucheva, Svitlana et al. (2015) Association of prostate cancer risk variants with gene expression in normal and tumor tissue. Cancer Epidemiol Biomarkers Prev 24:255-60|
|Yu, Ziyang; Chen, Sen; Sowalsky, Adam G et al. (2014) Rapid induction of androgen receptor splice variants by androgen deprivation in prostate cancer. Clin Cancer Res 20:1590-600|
|Crowe, Francesca L; Appleby, Paul N; Travis, Ruth C et al. (2014) Circulating fatty acids and prostate cancer risk: individual participant meta-analysis of prospective studies. J Natl Cancer Inst 106:|
|Cato, Laura; Neeb, Antje; Brown, Myles et al. (2014) Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L. Nucl Recept Signal 12:e005|
|Sun, T; Wang, X; He, H H et al. (2014) MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A. Oncogene 33:2790-800|
|Priolo, Carmen; Pyne, Saumyadipta; Rose, Joshua et al. (2014) AKT1 and MYC induce distinctive metabolic fingerprints in human prostate cancer. Cancer Res 74:7198-204|
|Kissick, Haydn T; Sanda, Martin G; Dunn, Laura K et al. (2014) Immunization with a peptide containing MHC class I and II epitopes derived from the tumor antigen SIM2 induces an effective CD4 and CD8 T-cell response. PLoS One 9:e93231|
Showing the most recent 10 out of 149 publications