The goals of the Biostatistics and Bioinformatics Core of the Prostate Cancer SPORE are (a) to maintain and continue to develop the clinical and tissue databases of the SPORE, (b) to provide experimental design, epidemiological and biostatistical expertise to all of the SPORE projects (c) to conduct data analysis and (d) to provide infrastructure and expertise for inter-SPORE and other scientific collaborations. The expertise of key members of this core facilitates planning, development and analysis of SPORE clinical trials, biomarker studies, molecular diagnostics and high throughput technologies such as DNA/RNA microarray, tissue microarray, proteomics experiments and retrospective studies. The SPORE Biostatistics and Bioinformatics Core leverages existing resources and expertise of the Biostatistics Shared Resource and the Bioinformatics Shared Resource of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. This enables the core to offer comprehensive bioinformatics and biostatistics services at minimal cost. During the past funding period, the Core has developed a fully operational, web-based, CDE-driven (common data element) central database for the SPORE that houses the clinical, tissue and laboratory data of prostate cancer patients seen at Northwestern Memorial Hospital (NMH), Jesse Brown (formerly Lakeside) Veterans Affairs Medical Center (VA), and Evanston Northwestern Healthcare (ENH) sites. The created database is essential to the SPORE as it provides means of obtaining timely and high quality specific information regarding patients in the SPORE. Procedures are in place whereby a standardized set of data are collected, checked, edited and entered from the various components of the SPORE. During the next funding period, the Core will expand to incorporate the University of Chicago, will increase the use of CDEs, incorporate technology and software coming from the NCI's caBIG initiative. The Biostatistics and Bioinformatics Core interacts extensively with the Clinical Trials and Advocacy Core and the Specimen Procurement Core of the SPORE. Direct interaction among the cores expedites data organization, data management and data analysis, enables the fluid creation of project-based teams for SPORE projects incorporating individuals with a broad range of expertise, and maximizes the efficiency of the SPORE-supported activities.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA090386-10
Application #
8444299
Study Section
Special Emphasis Panel (ZCA1-RPRB-M)
Project Start
Project End
Budget Start
2013-02-01
Budget End
2014-01-31
Support Year
10
Fiscal Year
2013
Total Cost
$205,416
Indirect Cost
$47,875
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Pascal, Laura E; Masoodi, Khalid Z; O'Malley, Katherine J et al. (2015) 5?-Reductase inhibition coupled with short off cycles increases survival in the LNCaP xenograft prostate tumor model on intermittent androgen deprivation therapy. J Urol 193:1388-93
Loeb, Stacy; Sanda, Martin G; Broyles, Dennis L et al. (2015) The prostate health index selectively identifies clinically significant prostate cancer. J Urol 193:1163-9
Grin, Boris; Loeb, Stacy; Roehl, Kim et al. (2015) A rare 8q24 single nucleotide polymorphism (SNP) predisposes North American men to prostate cancer and possibly more aggressive disease. BJU Int 115:101-5
Helenowski, Irene B; Demirtas, Hakan (2014) Multiple imputation of continuous data via a semiparametric probability integral transformation. J Biopharm Stat 24:359-77
Venkatasubramanian, Palamadai N; Brendler, Charles B; Plunkett, Beth A et al. (2014) Periprostatic adipose tissue from obese prostate cancer patients promotes tumor and endothelial cell proliferation: a functional and MR imaging pilot study. Prostate 74:326-35
Adams, Daniel L; Martin, Stuart S; Alpaugh, R Katherine et al. (2014) Circulating giant macrophages as a potential biomarker of solid tumors. Proc Natl Acad Sci U S A 111:3514-9
Ai, J; Pascal, L E; O'Malley, K J et al. (2014) Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model. Oncogene 33:2286-94
Pavese, Janet M; Ogden, Irene M; Voll, Eric A et al. (2014) Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis. PLoS One 9:e102289
Kregel, Steven; Szmulewitz, Russell Z; Vander Griend, Donald J (2014) The pluripotency factor Nanog is directly upregulated by the androgen receptor in prostate cancer cells. Prostate 74:1530-43
Wu, L; Runkle, C; Jin, H-J et al. (2014) CCN3/NOV gene expression in human prostate cancer is directly suppressed by the androgen receptor. Oncogene 33:504-13

Showing the most recent 10 out of 160 publications