The objective of the Vanderbilt GI SPORE Career Developmental Program (CDP) is to prepare individuals for successful careers in GI cancer research and care. Our track record of success is exemplary. For example, two prior GI SPORE career development recipients (designated Scholars) have leadership roles in this competitive renewal (Ethan Lee, Co-Investigator Project 1;Harvey Murff, Clinical PI Project 4). Scholars are selected via two established mechanisms: the Vanderbilt Physician Scientist Development (VPSD) Award and the GI SPORE Career Opportunity Award (COA). The VPSD track is designed for junior faculty with an MD or MD/PhD degree who are provided two years of support with 75% time for research and training. The COA track is more flexible and provides one to two years of support to MDs and/or PhDs at any level. It is designed to attract junior PhD investigators to enter GI cancer research and to encourage established investigators to transition to GI cancer research. Training in both tracks is tailored to the individual investigator, is overseen by the CDP Mentoring Panel and is supported by myriad institutional resources that assure our Scholars thrive. Scholars form an interdisciplinary mentoring committee, participate in regular work-in-progress presentations, receive formal evaluation each year, participate in a twice-monthly career development seminar series and are regulariy exposed to case studies on responsible conduct of research. They have access to: 1) biostatistics consultation;2) manuscript preparation workgroups;3) technical editing of completed products;3) studios with experts to vet scientific ideas, research designs and aims;4) robust intramural pilot and feasibility funding;and 5) grant writing support, including grant workshops, a funded grant library and mock study sections. Tools are in place to evaluate both mentees and mentors and to continuously enhance our program. Further oversight is provided by the Office of Clinical and Translational Scientist Development (CTSD) and the GI SPORE Administrative Core. Combined, these efforts ensure that we carefully foster excellence in the next generation of GI researchers.

Public Health Relevance

The VICC GI SPORE CDP will provide two tracks for careers in translational GI cancer research. The VPSD track is for junior physician-scientists who are provided 75% protected time for mentored research and training. The more flexible COA track is to attract junior PhD investigators to GI cancer research and to encourage established investigators to transition to GI cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
2P50CA095103-11
Application #
8343735
Study Section
Special Emphasis Panel (ZCA1-RPRB-M (M1))
Project Start
1997-02-28
Project End
2017-04-30
Budget Start
2012-09-07
Budget End
2013-04-30
Support Year
11
Fiscal Year
2012
Total Cost
$70,061
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Herring, Charles A; Chen, Bob; McKinley, Eliot T et al. (2018) Single-Cell Computational Strategies for Lineage Reconstruction in Tissue Systems. Cell Mol Gastroenterol Hepatol 5:539-548
Choi, Eunyoung; Lantz, Tyler L; Vlacich, Gregory et al. (2018) Lrig1+ gastric isthmal progenitor cells restore normal gastric lineage cells during damage recovery in adult mouse stomach. Gut 67:1595-1605
Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315
Idrees, Kamran; Padmanabhan, Chandrasekhar; Liu, Eric et al. (2018) Frequent BRAF mutations suggest a novel oncogenic driver in colonic neuroendocrine carcinoma. J Surg Oncol 117:284-289
Zhang, Qin; Jeppesen, Dennis K; Higginbotham, James N et al. (2018) Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells. Cell Mol Gastroenterol Hepatol 5:627-629.e6
Choksi, Yash A; Reddy, Vishruth K; Singh, Kshipra et al. (2018) BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Mucosal Immunol 11:1363-1374
Saito-Diaz, Kenyi; Benchabane, Hassina; Tiwari, Ajit et al. (2018) APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. Dev Cell 44:566-581.e8
Davenport, James R; Su, Timothy; Zhao, Zhiguo et al. (2018) Modifiable lifestyle factors associated with risk of sessile serrated polyps, conventional adenomas and hyperplastic polyps. Gut 67:456-465
Liu, Qi; Herring, Charles A; Sheng, Quanhu et al. (2018) Quantitative assessment of cell population diversity in single-cell landscapes. PLoS Biol 16:e2006687
Means, Anna L; Freeman, Tanner J; Zhu, Jing et al. (2018) Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer. Cell Mol Gastroenterol Hepatol 6:257-276

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