The overall objective of the Vanderbilt GI SPORE Developmental Research Program (DRP) is to encourage innovative translational research in GI neoplasia. The GI SPORE DRP uses an established and highly effective procedure to solicit applications twice yearly from investigators at Vanderbilt and Meharry Medical College. Pilot projects are evaluated by internal and external reviewers, including members of the GI SPORE External Advisory Board (EAB), using the NIH 9-point scoring system. Proposals are reviewed for scientific merit and the likelihood of leading to extramural funding. Special emphasis Is placed on attracting young investigators into GI cancer research, high risk/high gain projects, and emerging technologies and their application to GI cancer research. The DRP Director and Co-Directors make the final selections. With generous institutional support, we propose to fund four projects per year up to $50,000 per project.
The DRP is designed to fund pilot projects or early stage projects that are based on more limited scientific background but have the potential to produce important early data that can lead to larger, high-impact projects and future grants. By funding these projects, we encourage the development of new ideas, new technologies and exciting opportunities for us to explore further within the Gl research program.
|Jin, Ming; Roth, Rachel; Rock, Jonathan B et al. (2015) The impact of tumor deposits on colonic adenocarcinoma AJCC TNM staging and outcome. Am J Surg Pathol 39:109-15|
|Johnson, Adam; Wright, Jesse P; Zhao, Zhiguo et al. (2015) Cadherin 17 is frequently expressed by 'sclerosing variant' pancreatic neuroendocrine tumour. Histopathology 66:225-33|
|Peng, DunFa; Hu, TianLing; Soutto, Mohammed et al. (2014) Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma. Gut 63:540-51|
|Tripathi, Manish K; Deane, Natasha G; Zhu, Jing et al. (2014) Nuclear factor of activated T-cell activity is associated with metastatic capacity in colon cancer. Cancer Res 74:6947-57|
|Powell, Anne E; Vlacich, Gregory; Zhao, Zhen-Yang et al. (2014) Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis. Am J Physiol Gastrointest Liver Physiol 307:G16-23|
|Hight, Matthew R; Cheung, Yiu-Yin; Nickels, Michael L et al. (2014) A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells. Clin Cancer Res 20:2126-35|
|Zhang, Bing; Wang, Jing; Wang, Xiaojing et al. (2014) Proteogenomic characterization of human colon and rectal cancer. Nature 513:382-7|
|Mitra, Ramkrishna; Edmonds, Mick D; Sun, Jingchun et al. (2014) Reproducible combinatorial regulatory networks elucidate novel oncogenic microRNAs in non-small cell lung cancer. RNA 20:1356-68|
|Sekhar, Konjeti R; Benamar, Mouadh; Venkateswaran, Amudhan et al. (2014) Targeting nucleophosmin 1 represents a rational strategy for radiation sensitization. Int J Radiat Oncol Biol Phys 89:1106-14|
|Sehdev, Vikas; Katsha, Ahmed; Arras, Janet et al. (2014) HDM2 regulation by AURKA promotes cell survival in gastric cancer. Clin Cancer Res 20:76-86|
Showing the most recent 10 out of 239 publications