The overall objective of the Vanderbilt GI SPORE Developmental Research Program (DRP) is to encourage innovative translational research in GI neoplasia. The GI SPORE DRP uses an established and highly effective procedure to solicit applications twice yearly from investigators at Vanderbilt and Meharry Medical College. Pilot projects are evaluated by internal and external reviewers, including members of the GI SPORE External Advisory Board (EAB), using the NIH 9-point scoring system. Proposals are reviewed for scientific merit and the likelihood of leading to extramural funding. Special emphasis Is placed on attracting young investigators into GI cancer research, high risk/high gain projects, and emerging technologies and their application to GI cancer research. The DRP Director and Co-Directors make the final selections. With generous institutional support, we propose to fund four projects per year up to $50,000 per project.

Public Health Relevance

The DRP is designed to fund pilot projects or early stage projects that are based on more limited scientific background but have the potential to produce important early data that can lead to larger, high-impact projects and future grants. By funding these projects, we encourage the development of new ideas, new technologies and exciting opportunities for us to explore further within the Gl research program.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA095103-13
Application #
8726915
Study Section
Special Emphasis Panel (ZCA1-RPRB-M)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
13
Fiscal Year
2014
Total Cost
$23,339
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Zhu, Shoumin; Soutto, Mohammed; Chen, Zheng et al. (2016) Helicobacter pylori-induced cell death is counteracted by NF-κB-mediated transcription of DARPP-32. Gut :
Parang, B; Bradley, A M; Mittal, M K et al. (2016) Myeloid translocation genes differentially regulate colorectal cancer programs. Oncogene 35:6341-6349
Hong, Jun; Chen, Zheng; Peng, Dunfa et al. (2016) APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts. Oncotarget 7:16688-702
McKenzie, Andrew J; Hoshino, Daisuke; Hong, Nan Hyung et al. (2016) KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes. Cell Rep 15:978-87
Hardbower, Dana M; Singh, Kshipra; Asim, Mohammad et al. (2016) EGFR regulates macrophage activation and function in bacterial infection. J Clin Invest 126:3296-312
Zhao, Yue; Liu, Qi; Acharya, Pankaj et al. (2016) High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML. Cell Rep 16:2003-16
Yu, Huapeng H; Dohn, Michael R; Markham, Nicholas O et al. (2016) p120-catenin controls contractility along the vertical axis of epithelial lateral membranes. J Cell Sci 129:80-94
Schulte, Michael L; Khodadadi, Alexandra B; Cuthbertson, Madison L et al. (2016) 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport. Bioorg Med Chem Lett 26:1044-7
Sievers, Chelsie K; Leystra, Alyssa A; Clipson, Linda et al. (2016) Understanding Intratumoral Heterogeneity: Lessons from the Analysis of At-Risk Tissue and Premalignant Lesions in the Colon. Cancer Prev Res (Phila) 9:638-41
Harris, Kelly L; Pulliam, Stephanie R; Okoro, Emmanuel et al. (2016) Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer. Oncotarget 7:28947-60

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