The mission of the Career Development Program in squamous cell carcinoma of the head and neck (SCCHN) is to stimulate basic, translational and clinical research in head and neck cancer by recruiting new and established investigators in the area of head and neck cancer. The Career Development Program within the SPORE provides financial support for this mission, while the infrastructure of the SPORE provides a stimulating mentoring environment. The Career Development Program has the following objectives: 1) To recruit physicians, scientists and physician-scientists to direct their research efforts to the field of head and neck cancer;and 2) To train and guide these investigators through the process of developing into outstanding investigators in translational head and neck cancer research, including laboratory, clinical and population science. The faculty within the SPORE has a long-standing record in mentoring postdoctoral fellows, young scientists and research-oriented clinicians for careers in translational research. In the initial funding period, we supported seven junior faculty members in the Career Development Program, including three women, one of whom is African-American. All seven CDP-supported faculty have received peer reviewed funding in SCCHN and/or achieved objective career advancement. We will continue to support two promising translational investigators per year. The currently funded Research Training Grant in Head and Neck Oncology (T32) will serve as one source of research-oriented candidates to fill these positions. The SPORE-initiated recruitment of new faculty will consider candidates identified through the existing recruitment processes, with special emphasis placed on seeking minority candidates and women.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA097190-09
Application #
8541594
Study Section
Special Emphasis Panel (ZCA1-GRB-I)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
9
Fiscal Year
2013
Total Cost
$166,476
Indirect Cost
$86,635
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Ledgerwood, Levi G; Kumar, Dhruv; Eterovic, Agda Karina et al. (2016) The degree of intratumor mutational heterogeneity varies by primary tumor sub-site. Oncotarget 7:27185-98
Wen, Yihui; Li, Hua; Zeng, Yan et al. (2016) MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin. Oncotarget 7:23300-11
Lang Kuhs, Krystle A; Pawlita, Michael; Gibson, Sandra P et al. (2016) Characterization of human papillomavirus antibodies in individuals with head and neck cancer. Cancer Epidemiol 42:46-52
Kiesel, Brian F; Parise, Robert A; Guo, Jianxia et al. (2016) Toxicity, pharmacokinetics and metabolism of a novel inhibitor of IL-6-induced STAT3 activation. Cancer Chemother Pharmacol 78:1225-1235
Lesseur, Corina; Diergaarde, Brenda; Olshan, Andrew F et al. (2016) Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer. Nat Genet 48:1544-1550
Scharping, Nicole E; Menk, Ashley V; Moreci, Rebecca S et al. (2016) The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction. Immunity 45:374-88
Trivedi, Sumita; Rosen, Clark A; Ferris, Robert L (2016) Current understanding of the tumor microenvironment of laryngeal dysplasia and progression to invasive cancer. Curr Opin Otolaryngol Head Neck Surg 24:121-7
Walline, Heather M; Carey, Thomas E; Goudsmit, Christine M et al. (2016) High-Risk HPV, Biomarkers, and Outcome in Matched Cohorts of Head and Neck Cancer Patients Positive and Negative for HIV. Mol Cancer Res :
Chiosea, Simion I; Thompson, Lester D R; Weinreb, Ilan et al. (2016) Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations. Cancer 122:3136-3144
Li, Hua; Wheeler, Sarah; Park, Yongseok et al. (2016) Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts. Mol Cancer Res 14:278-86

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