The UCSF Brain Tumor SPORE proposal has 4 overall specific objectives: 1) to identify factors that contribute to the likelihood of surviving brain cancer;2) to identify spectroscopic, non-invasively derived imaging parameters and linked tissue biomarkers that can help predict recurrence and outcome in patients with low grade glioma;3) to develop improved therapies for pediatric brain tumors harboring BRAF mutations;and 4) to improve the immunotherapy of brain cancer. The Administrative Core of the UCSF Brain Tumor SPORE has been created to supervise the activities of the UCSF Brain Tumor SPORE and to provide fiscal management, administrative support, and the framework by which researchers can communicate and interact.
The aims of the Core are: 1. To evaluate research progress. The Administrative Core, through the SPORE Executive Committee, the SPORE Steering Committee, and the SPORE External Advisory Board, will be responsible for evaluating the progress of projects and making decisions regarding the continuation/replacement of projects. 2. To provide fiscal management. The Administrative Core will distribute funds from the SPORE Award, the Career Development and Developmental Research Programs, SPORE Supplement Awards, and discretionary funds provided by the institution. The Administrative Core will also be responsible for the timely reporting of finances to Project Leaders and the SPORE PI/co-Pls. 3. To provide administrative support. The Administrative Core will be responsible for the daily operations of the SPORE, for the preparation of SPORE-related manuscripts, and for communications with NIH. 4. To facilitate communication between SPORE investigators. The Administrative Core will be responsible for the scheduling of all meetings, seminar series, and retreats, and for the distribution of the notices inviting participation in the Career Development Program and the Developmental Research Program. 5. To assist in compliance. The Administrative Core will be responsible for assuring compliance and scientific integrity of all components of the SPORE. The Administrative Core will be used by all Projects and Cores in the SPORE.

Public Health Relevance

Despite the best efforts of neurosurgeons and neuro-oncologists, both the incidence and mortality rates of brain cancer have remained stable over the past 20 years and in 2009 alone, over 12,000 individuals died from brain cancer. The work described in this SPORE application is intended to increase our understanding of this disease, as well as to apply what we learn in the clinical setting, and in the process to improve the lives of individuals with brain cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA097257-12
Application #
8760345
Study Section
Special Emphasis Panel (ZCA1-RPRB-7)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
12
Fiscal Year
2014
Total Cost
$165,799
Indirect Cost
$60,560
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Andersson, Ulrika; Wibom, Carl; Cederquist, Kristina et al. (2014) Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer. Neuro Oncol 16:1333-40
Krishnamachari, Bhuma; Il'yasova, Dora; Scheurer, Michael E et al. (2014) A pooled multisite analysis of the effects of female reproductive hormones on glioma risk. Cancer Causes Control 25:1007-13
Walsh, Kyle M; Codd, Veryan; Smirnov, Ivan V et al. (2014) Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet 46:731-5
Sandstrom, Richard S; Foret, Michael R; Grow, Douglas A et al. (2014) Epigenetic regulation by chromatin activation mark H3K4me3 in primate progenitor cells within adult neurogenic niche. Sci Rep 4:5371
Davies, Jason M; Robinson, Aaron E; Cowdrey, Cynthia et al. (2014) Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. J Neurosurg 120:331-6
Lupo, Janine M; Nelson, Sarah J (2014) Advanced magnetic resonance imaging methods for planning and monitoring radiation therapy in patients with high-grade glioma. Semin Radiat Oncol 24:248-58
Ostrom, Quinn T; Bauchet, Luc; Davis, Faith G et al. (2014) The epidemiology of glioma in adults: a "state of the science" review. Neuro Oncol 16:896-913
Johnson, Brett E; Mazor, Tali; Hong, Chibo et al. (2014) Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 343:189-93
Lee, Seung-Tae; Bracci, Paige; Zhou, Mi et al. (2014) Interaction of allergy history and antibodies to specific varicella-zoster virus proteins on glioma risk. Int J Cancer 134:2199-210
Ohba, Shigeo; Mukherjee, Joydeep; See, Wendy L et al. (2014) Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance. Cancer Res 74:4836-44

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