The Biostatistics and Bioinformatics Gore serves multiple needs for the planning and conduct of the SPORE'S basic and translational research. The Gore provides hypothesis refinement, experimental design, analysis, data management, and informative presentation of results across all projects of the SPORE. From a biostatistical perspective, design and analysis of laboratory and clinical projects are performed at the direction of Dr. Peter Mueller. Dr.
C aimi ao Wei contributes her expertise to the analysis of microarray and genome data in this SPORE. Data from SPORE clinical trials, animal studies, and laboratory experiments are analyzed with the support of Dr. Chariotte Sun, Mr. Mark Munsell, and Ms. Diana Urbauer. Dr. Jonas Almeida will oversee data base management and data integration. Data integration will build on a new deployment of the existing data service SSDB. This SPORE resource is used to augment existing M.D. Anderson biostatistics and bioinformatics resources and to align these considerable resources with SPORE research objectives.
The Specific Aims ofthe Biostatistics and Bioinformatics Gore are:
Specific Aim 1 : To provide guidance in the design and conduct of clinical trials and other experiments arising from the ongoing research ofthe SPORE.
Specific Aim 2 : To provide the innovative statistical modeling, simulation techniques, and data analyses needed by the Projects, Developmental Projects, and other Gores to achieve their Specific Aims.
Specific Aim 3 : To ensure that the results of all Projects are based on well-designed experiments and are appropriately interpreted.
Specific Aim 4 : Provide a web-based environment where data bases can be created and shared within the multi-institutional Uterine SPORE scientific community.
The Biostatics and Bioinformatics Core will provide statistical and bioinformatics analyses as well as data management to all projects, cores, and developmental research and career development program investigators. The Gore will be involved in all aspects of the projects from the developmental to final evaluation stages and will provide the necessary services to ensure high quality analyses for optimal utilization of data resulting from the SPORE studies.
|Pakish, Janelle B; Zhang, Qian; Chen, Zhongyuan et al. (2017) Immune Microenvironment in Microsatellite-Instable Endometrial Cancers: Hereditary or Sporadic Origin Matters. Clin Cancer Res 23:4473-4481|
|Zang, Yong; Yuan, Ying (2017) Optimal sequential enrichment designs for phase II clinical trials. Stat Med 36:54-66|
|Haemmerle, Monika; Taylor, Morgan L; Gutschner, Tony et al. (2017) Platelets reduce anoikis and promote metastasis by activating YAP1 signaling. Nat Commun 8:310|
|Noh, Kyunghee; Mangala, Lingegowda S; Han, Hee-Dong et al. (2017) Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis. Cell Rep 21:2785-2795|
|Kurnit, Katherine C; Kim, Grace N; Fellman, Bryan M et al. (2017) CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence. Mod Pathol 30:1032-1041|
|Harjes, U; Bridges, E; Gharpure, K M et al. (2017) Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4. Oncogene 36:912-921|
|Suh, Han Na; Kim, Moon Jong; Jung, Youn-Sang et al. (2017) Quiescence Exit of Tert+ Stem Cells by Wnt/?-Catenin Is Indispensable for Intestinal Regeneration. Cell Rep 21:2571-2584|
|Soliman, Pamela T; Westin, Shannon N; Dioun, Shayan et al. (2017) A prospective validation study of sentinel lymph node mapping for high-risk endometrial cancer. Gynecol Oncol 146:234-239|
|Bruegl, Amanda S; Kernberg, Annessa; Broaddus, Russell R (2017) Importance of PCR-based Tumor Testing in the Evaluation of Lynch Syndrome-associated Endometrial Cancer. Adv Anat Pathol 24:372-378|
|Nagaraja, Archana S; Dood, Robert L; Armaiz-Pena, Guillermo et al. (2017) Adrenergic-mediated increases in INHBA drive CAF phenotype and collagens. JCI Insight 2:|
Showing the most recent 10 out of 541 publications