The goal of the Career Development Program of this uterine SPORE is to develop highly trained investigators dedicated to translational studies in human uterine cancer. The program will 1) recruit and train physician and basic science postdoctoral fellows to enable them to become highly skilled translational investigators in the field of uterine cancer, 2) provide specific knowledge of research in uterine cancer that will enhance the ability of awardees to conduct innovative translational science that will direcfiy impact on the understanding and treatment of this disease, and 3) redirect individuals who already have shown considerable scientific promise into uterine cancer research. The unique educational environment that exists at UT M.D. Anderson Gancer Center, the University of Texas Health Science Center, and the other institutions of the Texas Medical Center will add much to achieving these goals. Solicitations will be made for qualified candidates from UT M.D. Anderson Gancer Center, including physicians in our Gynecological Oncology and Pathology fellowship programs, basic science graduates of our Graduate School of Biomedical Sciences, and residents/fellows in the Department of Obstetrics, Gynecology, and Reproductive Sciences at the UT Houston Medical School, as well M.D. and Ph.D. candidates identified by national advertisements. The Career Development Selecfion Committee will interview the candidates, make the final selection of fellows, and approve the placement of the trainee in a research laboratory making this decision based upon the interests and research experience of the trainee and the availability of suitable resources. Minorities and women will be encouraged to apply. In addifion to research training via their individual projects, fellows will participate in activities designed to provide an overview of current knowledge, problems, and opportunities in uterine cancer research, state-of-the-art techniques and approaches for translafional research, career development activities such as grant preparafion and seminar presentations, and the opportunities to interact with established senior invesfigators in human uterine cancer research. This program will be directed by George M. Stancel, Ph.D.. Dean of the University of Texas Graduate School of Biomedical Sciences. David M. Gershenshon, M.D., Chairman of Gynecological Oncology at M. D Anderson, and Diane C. Bodurka, M.D., Gynecologic Oncologist at M. D. Anderson and Director of the Gynecologic Oncology Fellowship Program at M. D. Anderson Gancer Center. All have extensive mentoring experience.

Public Health Relevance

The purpose of the M. D. Anderson Uterine SPORE Career Development Program is to support the development of young investigators who intend to focus their careers on translational studies of endometrial cancer and who have not yet received peer-reviewed funding but who have potential as leaders in this field.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-RPRB-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas MD Anderson Cancer Center
United States
Zip Code
Pakish, Janelle B; Zhang, Qian; Chen, Zhongyuan et al. (2017) Immune Microenvironment in Microsatellite-Instable Endometrial Cancers: Hereditary or Sporadic Origin Matters. Clin Cancer Res 23:4473-4481
Zang, Yong; Yuan, Ying (2017) Optimal sequential enrichment designs for phase II clinical trials. Stat Med 36:54-66
Haemmerle, Monika; Taylor, Morgan L; Gutschner, Tony et al. (2017) Platelets reduce anoikis and promote metastasis by activating YAP1 signaling. Nat Commun 8:310
Noh, Kyunghee; Mangala, Lingegowda S; Han, Hee-Dong et al. (2017) Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis. Cell Rep 21:2785-2795
Kurnit, Katherine C; Kim, Grace N; Fellman, Bryan M et al. (2017) CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence. Mod Pathol 30:1032-1041
Harjes, U; Bridges, E; Gharpure, K M et al. (2017) Antiangiogenic and tumour inhibitory effects of downregulating tumour endothelial FABP4. Oncogene 36:912-921
Suh, Han Na; Kim, Moon Jong; Jung, Youn-Sang et al. (2017) Quiescence Exit of Tert+ Stem Cells by Wnt/?-Catenin Is Indispensable for Intestinal Regeneration. Cell Rep 21:2571-2584
Soliman, Pamela T; Westin, Shannon N; Dioun, Shayan et al. (2017) A prospective validation study of sentinel lymph node mapping for high-risk endometrial cancer. Gynecol Oncol 146:234-239
Bruegl, Amanda S; Kernberg, Annessa; Broaddus, Russell R (2017) Importance of PCR-based Tumor Testing in the Evaluation of Lynch Syndrome-associated Endometrial Cancer. Adv Anat Pathol 24:372-378
Nagaraja, Archana S; Dood, Robert L; Armaiz-Pena, Guillermo et al. (2017) Adrenergic-mediated increases in INHBA drive CAF phenotype and collagens. JCI Insight 2:

Showing the most recent 10 out of 541 publications