The goal of the Career Development Program of this uterine SPORE is to develop highly trained investigators dedicated to translational studies in human uterine cancer. The program will 1) recruit and train physician and basic science postdoctoral fellows to enable them to become highly skilled translational investigators in the field of uterine cancer, 2) provide specific knowledge of research in uterine cancer that will enhance the ability of awardees to conduct innovative translational science that will direcfiy impact on the understanding and treatment of this disease, and 3) redirect individuals who already have shown considerable scientific promise into uterine cancer research. The unique educational environment that exists at UT M.D. Anderson Gancer Center, the University of Texas Health Science Center, and the other institutions of the Texas Medical Center will add much to achieving these goals. Solicitations will be made for qualified candidates from UT M.D. Anderson Gancer Center, including physicians in our Gynecological Oncology and Pathology fellowship programs, basic science graduates of our Graduate School of Biomedical Sciences, and residents/fellows in the Department of Obstetrics, Gynecology, and Reproductive Sciences at the UT Houston Medical School, as well M.D. and Ph.D. candidates identified by national advertisements. The Career Development Selecfion Committee will interview the candidates, make the final selection of fellows, and approve the placement of the trainee in a research laboratory making this decision based upon the interests and research experience of the trainee and the availability of suitable resources. Minorities and women will be encouraged to apply. In addifion to research training via their individual projects, fellows will participate in activities designed to provide an overview of current knowledge, problems, and opportunities in uterine cancer research, state-of-the-art techniques and approaches for translafional research, career development activities such as grant preparafion and seminar presentations, and the opportunities to interact with established senior invesfigators in human uterine cancer research. This program will be directed by George M. Stancel, Ph.D.. Dean of the University of Texas Graduate School of Biomedical Sciences. David M. Gershenshon, M.D., Chairman of Gynecological Oncology at M. D Anderson, and Diane C. Bodurka, M.D., Gynecologic Oncologist at M. D. Anderson and Director of the Gynecologic Oncology Fellowship Program at M. D. Anderson Gancer Center. All have extensive mentoring experience.

Public Health Relevance

The purpose of the M. D. Anderson Uterine SPORE Career Development Program is to support the development of young investigators who intend to focus their careers on translational studies of endometrial cancer and who have not yet received peer-reviewed funding but who have potential as leaders in this field.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA098258-08
Application #
8382334
Study Section
Special Emphasis Panel (ZCA1-RPRB-M)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
8
Fiscal Year
2012
Total Cost
$88,844
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Bolivar, Ana M; Luthra, Rajyalakshmi; Mehrotra, Meenakshi et al. (2018) Targeted next-generation sequencing of endometrial cancer and matched circulating tumor DNA: identification of plasma-based, tumor-associated mutations in early stage patients. Mod Pathol :
Yuan, Xiaoyi; Lee, Jae W; Bowser, Jessica L et al. (2018) Targeting Hypoxia Signaling for Perioperative Organ Injury. Anesth Analg 126:308-321
Du, Di; Ma, Wencai; Yates, Melinda S et al. (2018) Predicting high-risk endometrioid carcinomas using proteins. Oncotarget 9:19704-19715
Sun, Chaoyang; Yin, Jun; Fang, Yong et al. (2018) BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency. Cancer Cell 33:401-416.e8
Hu, Xiaowen; Sood, Anil K; Dang, Chi V et al. (2018) The role of long noncoding RNAs in cancer: the dark matter matters. Curr Opin Genet Dev 48:8-15
Kim, Grace; Kurnit, Katherine C; Djordjevic, Bojana et al. (2018) Nuclear ?-catenin localization and mutation of the CTNNB1 gene: a context-dependent association. Mod Pathol 31:1553-1559
Yoo, Jung-Yoon; Kang, Hee-Bum; Broaddus, Russell R et al. (2018) MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT. BMC Cancer 18:605
Yuan, Ying; Lin, Ruitao; Li, Daniel et al. (2018) Time-to-Event Bayesian Optimal Interval Design to Accelerate Phase I Trials. Clin Cancer Res 24:4921-4930
Yates, Melinda S; Coletta, Adriana M; Zhang, Qian et al. (2018) Prospective Randomized Biomarker Study of Metformin and Lifestyle Intervention for Prevention in Obese Women at Increased Risk for Endometrial Cancer. Cancer Prev Res (Phila) 11:477-490
Yan, F; Thall, P F; Lu, K H et al. (2018) Phase I-II clinical trial design: a state-of-the-art paradigm for dose finding. Ann Oncol 29:694-699

Showing the most recent 10 out of 578 publications