The overall goal of the University of Texas M. D. Anderson Gancer Center Gynecologic SPORE for Uterine Cancers is to provide initial funding to support innovative translational studies and exploratory research in the area of gynecologic oncology and uterine cancer research. The support of translational research projects that can generate clinically testable hypotheses aimed at reducing the incidence and mortality of uterine cancers or leading to improved therapeutic outcomes or quality of life for uterine cancer patients will be emphasized. Pre-proposals in the form of project abstracts (1/2 -1 page) will be solicited by the Program and applicants of responsive abstracts invited to submit full Pilot Project proposals to the program. Proposals will follow an abbreviated ROI research grant format and be up to 5 pages in length. The Developmental Research Program Directors, in conjunction with the Executive Committee of the SPORE, will help investigators submitting proposals formulate relevant translational research aims and plans, as many investigators may not have previous expertise in this area. This process will therefore be a major educational activity that is anticipated to further stimulate translational research in gynecologic oncology and encourage the participation of both basic researchers and clinicians in translational research. Opportunities for competing renewals will be extended to all awardees. The proposals will be reviewed by members of the SPORE Executive Committee. Internal Advisory Committee, and External Advisory Committee. With the input from the Internal and External Advisory Committees, the SPORE Executive Committee will make the final selection of Pilot Projects for funding. Projects will be funded for 1 year with the possibility of renewal for an additional year. It is anticipated that the program will fund 2 Pilot Projects each year. All projects will be reviewed at the end of their first year with written progress reports and oral presentations at one of the SPORE meetings or retreats. Projects receiving an additional year of support will submit a final progress report at the end of their second year. Examples of Pilot Project abstracts are presented to illustrate the type of multidisciplinary translational research proposals that are anticipated to be received by the program.
The purpose of the Developmental Research program is to fund promising projects by investigators in any stage of their career whose work may not focus exclusively on endometrial cancer, but who propose innovative translational studies of endometrial cancer that could become full SPORE projects or compete successfully for funding outside ofthe SPORE.
|Bottsford-Miller, Justin; Choi, Hyun-Jin; Dalton, Heather J et al. (2015) Differential platelet levels affect response to taxane-based therapy in ovarian cancer. Clin Cancer Res 21:602-10|
|Wen, Yunfei; Graybill, Whitney S; Previs, Rebecca A et al. (2015) Immunotherapy targeting folate receptor induces cell death associated with autophagy in ovarian cancer. Clin Cancer Res 21:448-59|
|Previs, Rebecca A; Coleman, Robert L; Harris, Adrian L et al. (2015) Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer. Clin Cancer Res 21:955-61|
|Yang, Lifeng; Moss, Tyler; Mangala, Lingegowda S et al. (2014) Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer. Mol Syst Biol 10:728|
|Cho, Min Soon; Vasquez, Hernan G; Rupaimoole, Rajesha et al. (2014) Autocrine effects of tumor-derived complement. Cell Rep 6:1085-95|
|Yang, Yang; Han, Leng; Yuan, Yuan et al. (2014) Gene co-expression network analysis reveals common system-level properties of prognostic genes across cancer types. Nat Commun 5:3231|
|Wu, Sherry Y; Lopez-Berestein, Gabriel; Calin, George A et al. (2014) RNAi therapies: drugging the undruggable. Sci Transl Med 6:240ps7|
|Cancer Genome Atlas Research Network (2014) Comprehensive molecular characterization of gastric adenocarcinoma. Nature 513:202-9|
|Peng, Guang; Chun-Jen Lin, Curtis; Mo, Wei et al. (2014) Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun 5:3361|
|Liu, Guoyan; Sun, Yan; Ji, Ping et al. (2014) MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer. J Pathol 233:308-18|
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