We have selected four developmental projects using the criteria that 'developmental projects should provide an avenue for introducing and integrating new investigators and innovative technologies and/or methodologies into the ICMIC infrastructure and molecular imaging'. The four developmental projects cover a range of topics, such as (i) force propagation in melanoma cancer progression, (ii) imaging peritumoral stromal depletion as a surrogate for treatment efficacy in pancreatic cancer, (iii) lung-specific Twist mediated epithelial to mesenchymal transition (EMT) in lung premetastatic niche, and (iv) blockade of the hypoxia inducible factor (HIF)-1 pathway in bone metastasis from renal cancer. Three of the developmental projects are contributed by clinician-scientists and demonstrate the strong engagement of clinicians in the JHU ICMIC Program. The developmental projects will utilize the infrastructure provided by the resources. These projects are also strongly interactive with the research components. As this is an area of high priority, we have obtained additional funds of $24K per year from the Chairman of the Sidney Kimmel Comprehensive Cancer Center, $10K per year from the Chairman of Biomedical Engineering, and $10K for the first two years from the Chairman of Radiation Oncology to supplement the Developmental Fund. We therefore anticipate funding 10-15 pilot projects within the course of the five-year program. During the previous funding period we supported eleven developmental projects. Six of these initial projects transformed into funded grants. We anticipate that the new developmental projects and the investigators will continue the exciting trend of high risk, high reward research of molecular imaging in cancer.

Public Health Relevance

The developmental projects that we have selected will enable outstanding investigators to incorporate molecular imaging to provide new perspectives and insights into their research. These developmental projects, if successful, will provide advances in the discovery and treatment of cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA103175-08
Application #
8566688
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
8
Fiscal Year
2013
Total Cost
$122,011
Indirect Cost
$43,945
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Nakamura, Hideki; Lee, Albert A; Afshar, Ali Sobhi et al. (2018) Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions. Nat Mater 17:79-89
Krishnamachary, Balaji; Danhier, Pierre; Kakkad, Samata et al. (2018) Hypoxia-Induced Reporter Genes with Different Half-Lives. Methods Mol Biol 1790:113-125
Plyku, Donika; Mena, Esther; Rowe, Steven P et al. (2018) Combined model-based and patient-specific dosimetry for 18F-DCFPyL, a PSMA-targeted PET agent. Eur J Nucl Med Mol Imaging 45:989-998
Pickett, Julie E; Thompson, John M; Sadowska, Agnieszka et al. (2018) Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone. Bone Res 6:13
Cheng, Menglin; Glunde, Kristine (2018) Magnetic Resonance Spectroscopy Studies of Mouse Models of Cancer. Methods Mol Biol 1718:331-345
van Zijl, Peter C M; Lam, Wilfred W; Xu, Jiadi et al. (2018) Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and analysis of the field-dependent saturation spectrum. Neuroimage 168:222-241
Lesniak, Wojciech G; Aboye, Teshome; Chatterjee, Samit et al. (2017) In vivo Evaluation of an Engineered Cyclotide as Specific CXCR4 Imaging Reagent. Chemistry 23:14469-14475
Xu, Jiadi; Chan, Kannie W Y; Xu, Xiang et al. (2017) On-resonance variable delay multipulse scheme for imaging of fast-exchanging protons and semisolid macromolecules. Magn Reson Med 77:730-739
Penet, Marie-France; Kakkad, Samata; Pathak, Arvind P et al. (2017) Structure and Function of a Prostate Cancer Dissemination-Permissive Extracellular Matrix. Clin Cancer Res 23:2245-2254
Salas Fragomeni, Roberto Andres; Menke, Joshua R; Holdhoff, Matthias et al. (2017) Prostate-Specific Membrane Antigen-Targeted Imaging With [18F]DCFPyL in High-Grade Gliomas. Clin Nucl Med 42:e433-e435

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