Core B, the Biostatistics and Research Informatics Core (BRIC) of the City of Hope Lymphoma SPORE, provides statistical expertise across all SPORE research activities, including study design, safety monitoring, data collection, data quality assurance, data analysis, and multi-center study site coordination. BRIC will ensure that the proposed research hypotheses will be addressed with appropriate measures, tests, and interpretation, whether the data come from epidemiological studies, basic science, translational, immunologic studies, imaging, or clinical trials. The centralized, comprehensive framework of BRIC assures each SPORE investigator access to statistical experts who have appropriate experience, interests and time to engage in the collaborative development of study designs, analysis plans, data analysis, interpretation, and abstract /manuscript preparation. The BRIC will also provide infrastructure for the management and integration of both existing and newly collected data through consistent and compatible data handling. The Core plays an integral role in the scientific development, execution, and analysis of ail projects in the SPORE, including the clinical trials Core investigators have extensive experience in quantitative methods for biomedical applications, including clinical, basic, and translational science studies, particularly in hematologic malignancies. BRIC is committed to collaboration, to help ensure the scientific integrity of the SPORE investigations, by participating in regular project and program meetings, and providing rigorous and innovative input on all statistical and information management matters arising within the projects.
The specific aims of BRIC are as follows:
Specific Aim 1. To support high quality data management through state-of-the-art information technologies, ensuring standardization, quality assurance, security, training, monitoring, and data integration, and multicenter coordination when appropriate.
Specific Aim 2. To provide biostatistical support to the Projects, Cores and Programs, by consulting on the design, data monitoring, analysis, statistical modeling, visualization, interpretation and publication of the data generated by SPORE activities.
As a critical shared resource of the Lymphoma SPORE, the purpose of the Biostatistics and Research Informatics Core (BRIC) is to provide the essential information management, quality assurance, experimental design, and biostatistical analysis resources required to conduct the ongoing and planned investigations of lymphoid malignancies.
|Herrmann, Andreas; Lahtz, Christoph; Nagao, Toshikage et al. (2017) CTLA4 Promotes Tyk2-STAT3-Dependent B-cell Oncogenicity. Cancer Res 77:5118-5128|
|Herrera, Alex F; Mei, Matthew; Low, Lawrence et al. (2017) Relapsed or Refractory Double-Expressor and Double-Hit Lymphomas Have Inferior Progression-Free Survival After Autologous Stem-Cell Transplantation. J Clin Oncol 35:24-31|
|Kortylewski, Marcin; Moreira, Dayson (2017) Myeloid cells as a target for oligonucleotide therapeutics: turning obstacles into opportunities. Cancer Immunol Immunother 66:979-988|
|Herrera, Alex F; Armand, Philippe (2017) Minimal Residual Disease Assessment in Lymphoma: Methods and Applications. J Clin Oncol 35:3877-3887|
|Won, Haejung; Moreira, Dayson; Gao, Chan et al. (2017) TLR9 expression and secretion of LIF by prostate cancer cells stimulates accumulation and activity of polymorphonuclear MDSCs. J Leukoc Biol 102:423-436|
|Gibson, Christopher J; Lindsley, R Coleman; Tchekmedyian, Vatche et al. (2017) Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma. J Clin Oncol 35:1598-1605|
|Herrera, Alex F; Rodig, Scott J; Song, Joo Y et al. (2017) Outcomes after Allogeneic Stem Cell Transplantation in Patients with Double-Hit and Double-Expressor Lymphoma. Biol Blood Marrow Transplant :|
|Urak, Ryan; Walter, Miriam; Lim, Laura et al. (2017) Ex vivo Akt inhibition promotes the generation of potent CD19CAR T cells for adoptive immunotherapy. J Immunother Cancer 5:26|
|Zhang, Chunyan; Xin, Hong; Zhang, Wang et al. (2016) CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer. Immunity 44:913-923|
|Beharry, Andrew A; Lacoste, Sandrine; O'Connor, Timothy R et al. (2016) Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker. J Am Chem Soc 138:3647-50|
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