The Biostatistics Core provides statistical collaboration and/or data management for each of the SPORE projects, the Developmental Research Program projects, the Career Development Program projects, and the other Cores. Each project In this application has received input from the Biostatistics Core on study design and analysis plans. The statistical needs of the projects span a range of approaches and analyses; the projects range from pre-clinical studies to clinical trials. The Biostatistics Core builds upon the innovative, time-tested procedures and systems developed by one of the largest statistical groups in the country, which has successfully collaborated on more than 13,000 clinical and basic research studies since 1966. The Biostatistics core will provide each investigator access to statistical expertise: collaborative development of study designs, data collection tools, analysis plans, state of the art statistical modeling, analysis and interpretation of high-dimensional data, data management activities, and abstract/presentation/publication preparation. Members of the core have experience in the management and integration of existing and newly collected data that ensures consistent and compatible data handling. This Core complements and assists the efforts of the Animal Core, Clinical Research Core, and the Pathology and Tissue Procurement Core. The strengths of the Biostatistics Core includes our collaborative relationship with the projects' and cores' investigators, our knowledge of and ability to utilize the established research databases, our access to the operational and statistical infrastructure already in place in the institution, and the combined expertise and experience of our personnel.
The Biostatistics Core is essential for the design, analysis, and unambiguous display of SPORE-generated data. The Core provides oversight of all SPORE related statistical activities, which allows synergies and efficiencies for systemic and programmatic initiatives beyond what can be achieved with individual statistical teams for each project.
|Hardcastle, Jayson; Mills, Lisa; Malo, Courtney S et al. (2017) Immunovirotherapy with measles virus strains in combination with anti-PD-1 antibody blockade enhances antitumor activity in glioblastoma treatment. Neuro Oncol 19:493-502|
|Robinson, Steven; Galanis, Evanthia (2017) Potential and clinical translation of oncolytic measles viruses. Expert Opin Biol Ther 17:353-363|
|Kurokawa, C; Geekiyanage, H; Allen, C et al. (2017) Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma. J Neurooncol 131:41-48|
|Kizilbash, Sani H; Gupta, Shiv K; Chang, Kenneth et al. (2017) Restricted Delivery of Talazoparib Across the Blood-Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma. Mol Cancer Ther 16:2735-2746|
|Melin, Beatrice S; Barnholtz-Sloan, Jill S; Wrensch, Margaret R et al. (2017) Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. Nat Genet 49:789-794|
|Yin, Xueqian; Kang, Jeong-Han; Andrianifahanana, Mahefatiana et al. (2017) Basolateral delivery of the type I transforming growth factor beta receptor is mediated by a dominant-acting cytoplasmic motif. Mol Biol Cell 28:2701-2711|
|Msaouel, Pavlos; Opyrchal, Mateusz; Dispenzieri, Angela et al. (2017) Clinical Trials with Oncolytic Measles Virus: Current Status and Future Prospects. Curr Cancer Drug Targets :|
|Heim, Joel B; Squirewell, Edwin J; Neu, Ancilla et al. (2017) Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix. Proc Natl Acad Sci U S A 114:3933-3938|
|Tivnan, Amanda; Heilinger, Tatjana; Ramsey, Joanne M et al. (2017) Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells. Oncotarget 8:16605-16620|
|Pekmezci, Melike; Rice, Terri; Molinaro, Annette M et al. (2017) Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. Acta Neuropathol 133:1001-1016|
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