? Stanford University has a rapidly expanding program for the molecular imaging of living subjects. Through significant investments by the University in new space, infrastructure, and new faculty recruitments the Molecular Imaging Program at Stanford (MIPS) was established. Dr. Sam Gambhir, Professor of Radiology and Bio-X was recruited and appointed by the Dean of the Medical School as Director of the MIPS. He works closely with Dr. Christopher Contag, Assistant Professor of Pediatrics, Co-Director of the MIPS. Together, Drs. Gambhil (Principal Investigator for this grant application) and Contag (Co-Principal Investigator) form a unique leadership team that spans the breadth of disciplines involved in multimodality molecular imaging. The MIPS is highly supported by the Deans of Medicine, Engineering, and Humanities & Sciences, Chairs of Radiology, Radiation Oncology, Bioengineering and other senior faculty who win also serve on the internal advisory board for this grant application. ? This application is for a novel application for an in vivo cellular and molecular imaging center at Stanford (ICMIC at Stanford) to continue the momentum to build the MIPS. The goal of the ICMIC at Stanford application is to provide better links between pre-clinical models of-cancer and the clinical management of cancer patients by novel research in multimodality molecular imaging. Four research projects focused on pre-clinical small animal cancer models that utilize multimodality molecular imaging to understand basic cancer biology and optimize novel cancer therapies, and four developmental projects spanning different components of the molecular imaging research chain are the main science driving this grant. Investigators from a variety of disciplines and expertise including Dr. Felsher-Medical Oncology, Dr. Chen-Radiochemistry, Dr. Rao-Chemistry, Dr. Schnitzer-Applied Physics, Dr. Boyer-Radiation Oncology, Dr. Blankenberg-Radiology, Dr. Levin-Medical Physics, Dr. Nolan-Cell & Molecular Biology, Dr. PlevritIs-Mathematical Modeling, and Dr. Napel-lmage Visualization are all committed to advancing the science of molecular imaging and to this research application in particular. Four specialized resources including 1-Chemistry/Radiochemistry, 2- Flow Cytometry, 3- Small Animal Imaging and 4- Quantitation & Visualization will help insure that the ICMIC at Stanford grant functions efficiently. Finally, a structure training program with 2 post-docs funded by the ICMIC at Stanford and 2 additional post-docs funded through matching funds from Stanford will insure the ability to train next-generation interdisciplinary leaders in molecular imaging. Stanford University, with support for this application from the NCI, is poised to be a major contributor to the research and training efforts for the rapidly growing field of molecular imaging. ? ?

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1-SRRB-9 (J1))
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Menkens, Anne E
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Stanford University
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Natarajan, Arutselvan; Patel, Chirag B; Ramakrishnan, Sindhuja et al. (2018) A Novel Engineered Small Protein for Positron Emission Tomography Imaging of Human Programmed Death Ligand-1 : Validation in Mouse Models and Human Cancer Tissues. Clin Cancer Res :
Sun, Yao; Zeng, Xiaodong; Xiao, Yuling et al. (2018) Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery. Chem Sci 9:2092-2097
Natarajan, Arutselvan; Patel, Chirag B; Habte, Frezghi et al. (2018) Dosimetry Prediction for Clinical Translation of 64Cu-Pembrolizumab ImmunoPET Targeting Human PD-1 Expression. Sci Rep 8:633
Habte, Frezghi; Natarajan, Arutselvan; Paik, David S et al. (2018) Quantification of Cerenkov Luminescence Imaging (CLI) Comparable With 3-D PET Standard Measurements. Mol Imaging 17:1536012118788637
Loft, Mathias Dyrberg; Sun, Yao; Liu, Changhao et al. (2017) Improved positron emission tomography imaging of glioblastoma cancer using novel 68Ga-labeled peptides targeting the urokinase-type plasminogen activator receptor (uPAR). Amino Acids 49:1089-1100
Natarajan, Arutselvan; Mayer, Aaron T; Reeves, Robert E et al. (2017) Development of Novel ImmunoPET Tracers to Image Human PD-1 Checkpoint Expression on Tumor-Infiltrating Lymphocytes in a Humanized Mouse Model. Mol Imaging Biol 19:903-914
Hori, Sharon Seiko; Lutz, Amelie M; Paulmurugan, Ramasamy et al. (2017) A Model-Based Personalized Cancer Screening Strategy for Detecting Early-Stage Tumors Using Blood-Borne Biomarkers. Cancer Res 77:2570-2584
Ronald, John A; Kim, Byung-Su; Gowrishankar, Gayatri et al. (2017) A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant. Cancer Res 77:2893-2902
Jiang, Lei; Tu, Yingfeng; Hu, Xiang et al. (2017) Pilot Study of 64Cu(I) for PET Imaging of Melanoma. Sci Rep 7:2574
Keu, Khun Visith; Witney, Timothy H; Yaghoubi, Shahriar et al. (2017) Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma. Sci Transl Med 9:

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