Effective procurement of tissues and other biospecimens, and their optimal utilization is vital for? meaningful translational research activities. The goal of the Biospecimen, Pathology and? Genotyping Core is to work with each SPORE research project and the Analytical Core to ensure? efficient and highly coordinated procurement, use and storage of human biosamples. The Core will? obtain and maintain a repository of biospecimens (including tumor tissue, premalignant tissue,? adjacent non-malignant tissue), serum, plasma, peripheral blood lymphocytes (including lymphoblastoid? cell lines) and their derivates such as DMA and RNA samples for laboratory use, with an effective? coding system for all laboratory specimens to ensure patient confidentiality and prevent experimental? bias. Continuous communication between the surgeons, research nurses, biostatisticians and? pathologists, as well as standardized operating procedures for activities will provide for optimal? biospecimen collection and accurate processing, analysis and storage of each sample. Samples will be? prepared for genotyping in an efficient manner in a CLIA certified laboratory that assures good quality? control while ensuring that these precious materials are not wasted. Thus, the functions of the? Biospecimen, Pathology and Genotyping Core are to facilitate acquisition, preservation, analysis and? dispersal of well-annotated clinical samples and to provide histopathologic characterization of tumor? tissues for all project investigators. Currently, the Human Tissue Research Core facility and the DNA? Sequencing and Genotyping Core Facility, shared resources of the University of Chicago Cancer? Center, provide normal and neoplastic human tissues as well as genotyping services for cancer? research, and are resources of expertise, collaborative support, and service for pathology,? immunohistochemistry, laser capture microdissection, tissue microarray preparation, nucleic acid? extraction and genomics analyses. The Biospecimen, Pathology and Genotyping Core of the? Breast Cancer SPORE will be integrated with the existing Shared Resources in order to provide a? coordinated, centralized, dedicated program for procuring, processing, and assessing biospecimens? and patient data from breast cancer patients and to provide these specimens for research projects? within the Breast SPORE and to other investigators with translational breast cancer research projects.? This CORE will interact closely with the Analytic and Bio-informatics Core of this SPORE to integrate? data into a single database and to provide specimens that meet the statistical requirements for breast? cancer translational research projects supported by this SPORE.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA125183-02
Application #
7479895
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
2
Fiscal Year
2007
Total Cost
$331,364
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Feng, Ye; Rhie, Suhn Kyong; Huo, Dezheng et al. (2017) Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry. Cancer Epidemiol Biomarkers Prev 26:1016-1026
Hon, Jason; Hwang, Michelle S; Charnetzki, Meara A et al. (2017) Kinetic characterization of the inhibition of protein tyrosine phosphatase-1B by Vanadyl (VO2+) chelates. J Biol Inorg Chem 22:1267-1279
Milne, Roger L (see original citation for additional authors) (2017) Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. Nat Genet 49:1767-1778
Johnston, Henry Richard; Hu, Yi-Juan; Gao, Jingjing et al. (2017) Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome. Sci Rep 7:46398
Huo, Dezheng; Hu, Hai; Rhie, Suhn K et al. (2017) Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas. JAMA Oncol 3:1654-1662
Nath, Aritro; Wang, Jacqueline; Stephanie Huang, R (2017) Pharmacogenetics and Pharmacogenomics of Targeted Therapeutics in Chronic Myeloid Leukemia. Mol Diagn Ther 21:621-631
Lecarpentier, Julie; Silvestri, Valentina; Kuchenbaecker, Karoline B et al. (2017) Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores. J Clin Oncol 35:2240-2250
Michailidou, Kyriaki (see original citation for additional authors) (2017) Association analysis identifies 65 new breast cancer risk loci. Nature 551:92-94
Geeleher, Paul; Huang, R Stephanie (2017) Exploring the Link between the Germline and Somatic Genome in Cancer. Cancer Discov 7:354-355
Rudin, Shoshana; Marable, Marcus; Huang, R Stephanie (2017) The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment. Genomics Proteomics Bioinformatics 15:82-93

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