The Biostatistics and Bioinformatics Core facility provides the statistical and computational support for all GI cancer SPORE investigators. The Core will support consultation and collaboration on all aspects of study design, database development and quality control, and analysis and interpretation of data. The statisticians and bioinformatics scientists participating in the Biostatistics and Bioinformatics Core have been chosen for their broad range of expertise and experience in clinical trials, laboratory experiments, genetics and genomics research, computational biology and epidemiology studies. Dr. Dianne Finkelstein and Dr. Hui Zheng have extensive experience as statisticians within the comprehensive cancer center and cooperative oncology group settings. Dr. John Quackenbush directs the Center for Cancer Computational Biology at the Dana-Farber Cancer Institute (DFCI) and has extensive experience in genomics and computational biology. Dr. Barbara Weir and Nicholas Stransky are computational biologists who have deep expertise in the development and deployment of methods to analyze and integrate genomic datasets. Collectively these individuals have affiliations at Massachusetts General Hospital (MGH), DFCI, Harvard Medical School (HMS), Harvard School of Public Health (HSPH) and the Broad Institute of Harvard and MIT. However, their SPORE collaborations will be based on areas of expertise and need and will involve investigators from several of the affiliate institutions. The Biostatistics and Bioinformatics Core members have participated regularly in the planning meetings where the scientific goals and research methods of the SPORE projects were discussed.
The specific aims of this core facility are to;1: Provide ready access to statistical and bioinformatics expertise and computing consultation to the GI cancer SPORE program;2: Provide biostatistical/bioinformatics expertise for the planning, analysis and reporting of laboratory experiments, epidemiology studies and clinical trials;3: Advise and support SPORE investigators and their data collectors (technicians, nurses, data managers, etc.) in the areas of data form design, data collection, record abstraction, computerization, database designing and management, and data quality control;4: Provide support for the development of integrative computational models to facilitate the analysis and interpretation of complex genomic datasets;5: Provide the scientific computing expertise required to meet the data management and analytical needs of GI cancer SPORE investigators.
During the last 20 years, the development of new statistical methodology for cancer research has resulted in an expanded role for the statistician in the research process and a higher standard for scientific evidence in a study. The Biostatistics and Bioinformatics Core facility provides the statistical and computational support for all GI cancer SPORE investigators. The Core will support consultation and collaboration on all aspects of study design, database development and quality control, and analysis and interpretation of data.
|Russo, Mariangela; Siravegna, Giulia; Blaszkowsky, Lawrence S et al. (2016) Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer. Cancer Discov 6:147-53|
|Kugel, Sita; SebastiÃ¡n, Carlos; Fitamant, Julien et al. (2016) SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b. Cell 165:1401-15|
|Kim, Sun A; Inamura, Kentaro; Yamauchi, Mai et al. (2016) Loss of CDH1 (E-cadherin) expression is associated with infiltrative tumour growth and lymph node metastasis. Br J Cancer 114:199-206|
|Delaney, Susan K; Hultner, Michael L; Jacob, Howard J et al. (2016) Toward clinical genomics in everyday medicine: perspectives and recommendations. Expert Rev Mol Diagn 16:521-32|
|Mima, Kosuke; Cao, Yin; Chan, Andrew T et al. (2016) Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location. Clin Transl Gastroenterol 7:e200|
|Whitley, Melodi Javid; Cardona, Diana M; Lazarides, Alexander L et al. (2016) A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. Sci Transl Med 8:320ra4|
|Ahronian, Leanne G; Corcoran, Ryan B (2016) Effective MAPK Inhibition is critical for therapeutic responses in colorectal cancer with BRAF mutations. Mol Cell Oncol 3:e1048405|
|Saha, Supriya K; Zhu, Andrew X; Fuchs, Charles S et al. (2016) Forty-Year Trends in Cholangiocarcinoma Incidence in the U.S.: Intrahepatic Disease on the Rise. Oncologist 21:594-9|
|Ou, Wen-Bin; Lu, Minmin; Eilers, Grant et al. (2016) Co-targeting of FAK and MDM2 triggers additive anti-proliferative effects in mesothelioma via a coordinated reactivation of p53. Br J Cancer 115:1253-1263|
|Lazarides, Alexander L; Whitley, Melodi J; Strasfeld, David B et al. (2016) A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma. Theranostics 6:155-66|
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