The Animal Models and Pathology Specialized Resource (Core D) of the Emory Molecular andTranslational Imaging Center (EMTIC) will assist the overall project by providing service in two criticalareas: animal models and histopathologic services. The Core is necessary for the success of theEMTIC and is highly integrative, being utilized by all four research projects and all five pilot projects.The animal models component will act to generate and characterize novel rodent models for molecularimaging in cancer research and will assist the individual projects by collecting and analyzing tumordata from these animals. The production and analysis of relevant animal models of cancer is central tothe EMTIC because of the heavy emphasis on the development and validation of novel tracers inpreclinical studies that could be utilized as markers for tumor detection, progression, anddissemination in vivo. The animal component will also serve as a repository for the preservation anddistribution of any novel transgenic strains of mice that may be utilized in the Research Projects andPilot Projects as they become necessary. The Core will perform necropsy and tissue collection forexperimental animals, and will collect tumor samples from selected animals for generation of cell linesfor use by EMTIC investigators. The pathology component of the Core will provide tissue and tumorprocurement expertise, tissue processing, as well as histological and immunohistochemical analysis oftumor samples from human disease and animal models. Histologic and immunohistochemicalevaluation of tumors from patients and animal models will be necessary in order to correlate andvalidate the detection of novel tracers by PET, MRI and optical methods with the targeted biomarkersin tissues.Thus the Animal Models and Pathology Core will contribute significantly to the overall goals of theEMTIC from a scientific perspective by providing these services as well as expertise. In addition, theinclusion of these services into a comprehensive core component will provide additional benefit toEMTIC as a whole, through consolidation of effort, avoidance of unnecessary experimental duplication,and by drawing upon the collective expertise of the Core personnel.
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