An important component of the Emory Molecular and Translational Imaging Center (EMTIC) is the establishment of a strong pilot program to foster the continued growth of cancer-targeted molecular imaging research at Emory by bringing new investigators into EMTIC. Through the availability of Developmental Funds for Pilot Projects supported at the level of $35,000/year per pilot project, EMTIC will foster a steady source of new ideas, applications areas for new methodologies developed within the Cores, and opportunities for both trainees and established scientists to acquire preliminary data in the quantitative molecular imaging arena on which to base competitive future R01 proposals. Five outstanding pilot projects were selected following the solicitation of pilot proposals from all faculty affiliated with the Winship Cancer Institute (WCI) and those in the Departments of Radiology at Emory University and/or Biomedical Engineering at Georgia Tech. The Pilot Projects were chosen using the following review criteria: 1) scientific strengths, including likelihood to lead to R01 funding, 2} """"""""fit"""""""" with the developing EMTIC vision, 3) was it potentially translational with a benefit to cancer patients, and 4) integration with institutional linkages and WCI programs. The Pilot Projects include: Pilot Project 1. Receptor-targeted Radiotracers for Detection of Pancreatic Cancer;Pilot Project 2. Optical Dissection of a Lung Cancer Tumor Suppressor;Pilot Project 3. Imaging Tumor HIF-1 Activity in a Rat Orthotopic Brain Tumor Model by MRI;Pilot Project 4, Identifying IFN-alpha-lnduced Microglial Activation Using C-11 PK11195 versus F-18 PK11195 in Rhesus Monkeys;and Pilot Project 5. Targeted """"""""Triggerable"""""""" Nanoscale Contrast Enhanced Cone Beam Computed Tomography (CBCT) for Early Breast Cancer Detection. The Pilot Projects are highly integrated with both EMTIC Research Projects and Cores to benefit and contribute to the overall mission of this center grant.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA128301-05
Application #
8382629
Study Section
Special Emphasis Panel (ZCA1-SRRB-9)
Project Start
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$84,911
Indirect Cost
$29,896
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Orza, Anamaria; Yang, Yi; Feng, Ting et al. (2016) A nanocomposite of Au-AgI core/shell dimer as a dual-modality contrast agent for x-ray computed tomography and photoacoustic imaging. Med Phys 43:589
Tian, Zhiqiang; Liu, Lizhi; Zhang, Zhenfeng et al. (2016) Superpixel-Based Segmentation for 3D Prostate MR Images. IEEE Trans Med Imaging 35:791-801
Dance, David R; Sechopoulos, Ioannis (2016) Dosimetry in x-ray-based breast imaging. Phys Med Biol 61:R271-R304
Schuster, David M; Nanni, Cristina; Fanti, Stefano (2016) PET Tracers Beyond FDG in Prostate Cancer. Semin Nucl Med 46:507-521
Odewole, Oluwaseun A; Oyenuga, Oyeladun A; Tade, Funmilayo et al. (2015) Reproducibility and reliability of anti-3-[¹⁸F]FACBC uptake measurements in background structures and malignant lesions on follow-up PET-CT in prostate carcinoma: an exploratory analysis. Mol Imaging Biol 17:277-83
Lu, Guolan; Wang, Dongsheng; Qin, Xulei et al. (2015) Framework for hyperspectral image processing and quantification for cancer detection during animal tumor surgery. J Biomed Opt 20:126012
Pike, Robert; Sechopoulos, Ioannis; Fei, Baowei (2015) A minimum spanning forest based classification method for dedicated breast CT images. Med Phys 42:6190-202
Qin, Xulei; Fei, Baowei (2015) DTI template-based estimation of cardiac fiber orientations from 3D ultrasound. Med Phys 42:2915-24
Kaluzova, Milota; Bouras, Alexandros; Machaidze, Revaz et al. (2015) Targeted therapy of glioblastoma stem-like cells and tumor non-stem cells using cetuximab-conjugated iron-oxide nanoparticles. Oncotarget 6:8788-806
Wang, Dongsheng; Fei, Baowei; Halig, Luma V et al. (2014) Targeted iron-oxide nanoparticle for photodynamic therapy and imaging of head and neck cancer. ACS Nano 8:6620-32

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