Project 2 proposes to develop fluorescent, PET, and SPECT imaging agents targeted to the enzyme, cyclooxygenase (COX)-2. COX-2 is highly expressed in many solid tumors but not in most untransformed epithelial tissues. Thus, it makes an attractive target for molecular imaging. All of the reviewers of this project agreed that there is a strong rationale for targeting COX-2. They also felt that the research was innovative because, although other laboratories have attempted to develop COX-targeted imaging agents, none have succeeded. Despite the high enthusiasm for the concept, the reviewers were critical of certain aspects of the proposed research plan.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA128323-05
Application #
8381568
Study Section
Special Emphasis Panel (ZCA1-SRRB-9)
Project Start
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$136,882
Indirect Cost
$47,703
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
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