ORGANIZATION AND ADMINISTRATION OF THE ICMIC [a] Structure and Advisory Groups The proposed ICMIC will be formed as a cohesive and interactive network of individual investigators and laboratories within Vanderbilt University, who will each undertake specific technical developments and research, but who will collaborate on the overall aims outlined in this proposal and use and support the Specialized Resources in an interactive manner. A critical mass of the personnel and laboratories involved (including the Small Animal Imaging and Chemistry Core laboratories and personnel, administrative personnel, director, 20 faculty and over 50 imaging trainees) are housed within contiguous spaces within our new VUIIS building, ensuring a very high degree of interaction. The new building will serve as the """"""""home"""""""" for the ICMIC, and it will provide space for visitors and investigators from other departments so that they may physically reside at least part-time within the environment of the imaging facilities and core laboratories. The primary research projects and partnering laboratories from within Vanderbilt are identified in the figure below. The membership of ICMIC will not be restricted, and we expect it will grow over time, but at the time of writing this proposal we have identified key specific investigators who will take leading roles in establishing the resource and pushing its research agenda. These individuals are described below. In addition, although the progress and integration of the ICMIC will rely on frequent and informal contacts between the members, these interactions will be strengthened by an organizational structure designed to ensure the aims of the ICMIC are fulfilled. A schematic diagram the structure is given in Figure B1. The overall activities of the VICMIC will be overseen by the PI, Dr Gore, with administrative and other support from the Vanderbilt University Institute of Imaging Science (VUIIS, a trans-institutional coalition of imaging scientists and staff housed mainly within the Medical Center). Dr. Gore will take overall responsibility for the administration of the core resources and the integration of the other various activities of the ICMIC, but decisions on the scientific directions and allocation of resources will be shared with Dr. Dennis Hallahan (who will act as co-Director of the ICMIC) and other members of an Executive Steering Group. Dr. Dennis Hallahan is Professor and Chairman of the Department of Radiation Oncology, Ingram Professor of Cancer Research, and Program Leader for the Host-Tumor Interaction Program within VICC (see below).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center (P50)
Project #
5P50CA128323-05
Application #
8381577
Study Section
Special Emphasis Panel (ZCA1-SRRB-9)
Project Start
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$59,204
Indirect Cost
$20,632
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Xu, Junzhong; Li, Ke; Smith, R Adam et al. (2017) A comparative assessment of preclinical chemotherapeutic response of tumors using quantitative non-Gaussian diffusion MRI. Magn Reson Imaging 37:195-202
Tang, Dewei; Li, Jun; Buck, Jason R et al. (2017) Evaluation of TSPO PET Ligands [18F]VUIIS1009A and [18F]VUIIS1009B: Tracers for Cancer Imaging. Mol Imaging Biol 19:578-588
Jiang, Xiaoyu; Li, Hua; Xie, Jingping et al. (2017) In vivo imaging of cancer cell size and cellularity using temporal diffusion spectroscopy. Magn Reson Med 78:156-164
Coffey, Aaron M; Shchepin, Roman V; Feng, Bibo et al. (2017) A pulse programmable parahydrogen polarizer using a tunable electromagnet and dual channel NMR spectrometer. J Magn Reson 284:115-124
Uddin, Md Jashim; Moore, Chauca E; Crews, Brenda C et al. (2016) Fluorocoxib A enables targeted detection of cyclooxygenase-2 in laser-induced choroidal neovascularization. J Biomed Opt 21:90503
Xu, Junzhong; Li, Hua; Li, Ke et al. (2016) Fast and simplified mapping of mean axon diameter using temporal diffusion spectroscopy. NMR Biomed 29:400-10
Uddin, Md Jashim; Werfel, Thomas A; Crews, Brenda C et al. (2016) Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer. Biomaterials 92:71-80
Haskett, Darren G; Maestas, David; Howerton, Stephen J et al. (2016) 2-Photon Characterization of Optical Proteolytic Beacons for Imaging Changes in Matrix-Metalloprotease Activity in a Mouse Model of Aneurysm. Microsc Microanal 22:349-60
Xie, Jingping; Wang, Chunxia; Gore, John C (2016) High Throughput Screening for Colorectal Cancer Specific Compounds. Comb Chem High Throughput Screen 19:180-8
Hassanein, Mohamed; Hight, Matthew R; Buck, Jason R et al. (2016) Preclinical Evaluation of 4-[18F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer. Mol Imaging Biol 18:18-23

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