The rapidly developing advancements in modern imaging technology requires ever more sophisticated animal models. This lends to cooperative efforts between experts in imaging and those with specialized skills in modeling human disease in animals. Hence an Animal Model and Care Core with expertise in a variety of animal models, procedures and husbandry will add to the overall synergy of the program. The Core aims to i) provide advice and expertise in experimental design, ii) assist in the preparation of animal protocols and amendments and coordinate with Environmental Health and Safety when appropriate, iii) streamline the acquisition and transfer of animals, and iv) provide procedural assistance as needed. The two main species in the ICMIC are mice and rabbits. To accomodate this need the work with mice will be coordinated at the John and Rebecca Moores Comprehensive UCSD Cancer Center. This new building has a state of the art vivarium that is located on the same level as the Small Animal Imaging Resource. The proximity of these two vital functions enhances the synergy to optimize the timing of the imaging in the sophisticated models. The rabbits will be housed in the Clinical Teaching Facility. The personnel of the Core will be able to provide assistance to the investigators that are using each of these facilities.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center (P50)
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Special Emphasis Panel (ZCA1-SRRB-9)
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University of California San Diego
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Qin, Zhengtao; Hoh, Carl K; Hall, David J et al. (2015) A tri-modal molecular imaging agent for sentinel lymph node mapping. Nucl Med Biol 42:917-22
Malone, Christopher D; Olson, Emilia S; Mattrey, Robert F et al. (2015) Tumor Detection at 3 Tesla with an Activatable Cell Penetrating Peptide Dendrimer (ACPPD-Gd), a T1 Magnetic Resonance (MR) Molecular Imaging Agent. PLoS One 10:e0137104
Goodwin, Andrew P; Nakatsuka, Matthew A; Mattrey, Robert F (2015) Stimulus-responsive ultrasound contrast agents for clinical imaging: motivations, demonstrations, and future directions. Wiley Interdiscip Rev Nanomed Nanobiotechnol 7:111-23
Sicklick, Jason K; Leonard, Stephanie Y; Babicky, Michele L et al. (2014) Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor. J Transl Med 12:41
Liss, Michael A; Farshchi-Heydari, Salman; Qin, Zhengtao et al. (2014) Preclinical evaluation of robotic-assisted sentinel lymph node fluorescence imaging. J Nucl Med 55:1552-6
Hosseini, Ava; Baker, Jennifer L; Tokin, Christopher A et al. (2014) Fluorescent-tilmanocept for tumor margin analysis in the mouse model. J Surg Res 190:528-34
Liberman, Alexander; Wu, Zhe; Barback, Christopher V et al. (2014) Hollow iron-silica nanoshells for enhanced high intensity focused ultrasound. J Surg Res 190:391-8
Felsen, Csilla N; Savariar, Elamprakash N; Whitney, Michael et al. (2014) Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma. Am J Physiol Lung Cell Mol Physiol 306:L764-74
Liss, Michael A; Stroup, Sean P; Qin, Zhengtao et al. (2014) Robotic-assisted fluorescence sentinel lymph node mapping using multimodal image guidance in an animal model. Urology 84:982.e9-14
Liberman, Alexander; Wu, Zhe; Barback, Christopher V et al. (2013) Color Doppler ultrasound and gamma imaging of intratumorally injected 500 nm iron-silica nanoshells. ACS Nano 7:6367-77

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